3'-(2-Hydroxy-3-morpholinopropoxy)acetophenone

Base Information

• Chemical Name: 3'-(2-Hydroxy-3-morpholinopropoxy)acetophenone
• CAS No.: 63990-82-9
• Molecular Formula: C15H21 N O4
• Molecular Weight: 279.3315
• Mol file: 63990-82-9.mol

Synonyms:1-(3-acetylphenoxy)-3-(morpholin-4-yl)-2-propanol;GPV 384

Chemical Property of 3'-(2-Hydroxy-3-morpholinopropoxy)acetophenone

Chemical Property:

• Vapor Pressure: 2.04E-09mmHg at 25°C
• Boiling Point: 464.2°Cat760mmHg
• Flash Point: 234.5°C
• PSA: 59.00000
• Density: 1.161g/cm³
• LogP: 0.89900

Purity/Quality:

99%min ^*data from raw suppliers

3'-((2-HYDROXY-3-MORPHOLINO)PROPOXY)ACETOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-(2-Hydroxy-3-morpholinopropoxy)acetophenone

There total 5 articles about 3'-(2-Hydroxy-3-morpholinopropoxy)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) + 1-[3-(2,3-epoxy-propoxy)-phenyl]-ethanone (42865-03-2) → 1-[3-(2-hydroxy-3-morpholin-4-yl-propoxy)-phenyl]-ethanone (63990-82-9)

Guidance literature:

In ethanol; for 8h; Heating;

Reference yield:

3-Hydroxyacetophenone (121-71-1) → 1-[3-(2-hydroxy-3-morpholin-4-yl-propoxy)-phenyl]-ethanone (63990-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (CF₃)3COH / chiral polymer-supported Co(salen) complex / 6 h / 4 - 25 °C

1.2: KOH / diethyl ether / 3 h / 25 °C

2.1: Yb(OTf)3 / CH₂Cl₂ / 16 h / 25 °C

With 1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol; ytterbium(III) triflate; chiral polymer-supported Co(salen) complex; In dichloromethane;

DOI:10.1021/ol990920q

Reference yield:

morpholine (110-91-8,99108-56-2) + C11H12O3 (250778-98-4) → 1-[3-(2-hydroxy-3-morpholin-4-yl-propoxy)-phenyl]-ethanone (63990-82-9)

Guidance literature:

With ytterbium(III) triflate; In dichloromethane; at 25 ℃; for 16h;

DOI:10.1021/ol990920q

upstream raw materials:

morpholine

1-[4-(2-oxiranylmethoxy)phenyl]-1-ethanone

1-[3-(2,3-epoxy-propoxy)-phenyl]-ethanone

C₁₁H₁₂O₃

Refernces

• 1、 Dwivedi,Shukla,Bhandari,Setty,Kamboj,Khanna. "1-Aryloxy-3-substituted aminopropan-2-ols, aminomethyl substituted phenols and 1,3-benzoxazines as potential spermicides". . p. 281 - 285. Retrieved 2007/10/02.