Aciclovir IMp. D (EP)

Base Information

• Chemical Name: Aciclovir IMp. D (EP)
• CAS No.: 59277-91-7
• Molecular Formula: C15H15N5O4
• Molecular Weight: 329.31100
• Mol file: 59277-91-7.mol

Synonyms:9-<2-Benzoyloxyaethoxymethyl>-guanin;9-(2-benzoyloxyethoxymethyl)guanine;HMS1608I20;2-amino-9-(2-benzoyloxy-ethoxymethyl)-1,9-dihydro-purin-6-one;

Chemical Property of Aciclovir IMp. D (EP)

Chemical Property:

• PKA: 9.34±0.20(Predicted)
• PSA: 126.11000
• Density: 1.51±0.1 g/cm3(Predicted)
• LogP: 0.87530

Purity/Quality:

above98% ^*data from raw suppliers

AcyclovirBenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Acyclovir Benzoate, is an intermediate used in the synthesis of Acyclovir-d4 (A192402), an orally active acyclic labeled nucleoside with inhibitory activity towards several herpes viruses. Antiviral.Acyclovir Benzoate is used in the method of treating warts.

Technology Process of Aciclovir IMp. D (EP)

There total 3 articles about Aciclovir IMp. D (EP) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

acycloguanosine (59277-89-3) + benzoic acid anhydride (93-97-0) → 2-amino-9-(2-benzoyloxy-ethoxymethyl)-1,9-dihydro-purin-6-one (59277-91-7)

Guidance literature:

With dmap; In N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1097-458X(199909)37:9<687::AID-MRC510>3.0.CO;2-K

Reference yield: 32.0%

(2-benzoyloxyethyl)oxymethyl chloride (58305-05-8) + 2-amino-1,9-dihydro-6H-purin-6-one (73-40-5) → 2-amino-9-(2-benzoyloxy-ethoxymethyl)-1,9-dihydro-purin-6-one (59277-91-7)

Guidance literature:

With ammonium sulfate; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In ethanol; benzene;

Reference yield:

→ 2-amino-9-(2-benzoyloxy-ethoxymethyl)-1,9-dihydro-purin-6-one (59277-91-7)

Guidance literature:

1)Guanin, (NH4)2SO4, Hexamethyldisiloxan, 2) Chlorid/BRN= 212064//Et3N;

upstream raw materials:

acycloguanosine

benzoic acid anhydride

(2-benzoyloxyethyl)oxymethyl chloride

2-amino-1,9-dihydro-6H-purin-6-one

Refernces

• 1、 -. "2-Amido-9-(2-acyloxyethoxymethyl)hypoxanthines". . . Retrieved 2008/06/13.