Mabuprofen

Base Information

Chemical Name:Mabuprofen
CAS No.:82821-47-4
Molecular Formula:C₁₅H₂₃NO₂
Molecular Weight:249.353
Hs Code.:
European Community (EC) Number:280-048-9
UNII:02B8S6J90B
DSSTox Substance ID:DTXSID90868676
Wikidata:Q27231513
NCI Thesaurus Code:C66046
ChEMBL ID:CHEMBL2105154
Mol file:82821-47-4.mol

Synonyms:Aminoprofen;Mabuprofen;82821-47-4;83394-44-9;Mabuprofen [INN];(+-)-Alminoprofen;Mabuprofene;Mabuprofeno;Mabuprofenum;Aldospray analgesico;AU-7801;N-(2-hydroxyethyl)-2-[4-(2-methylpropyl)phenyl]propanamide;N-(2-Hydroxyethyl)-alpha-methyl-4-(2-methylpropyl)benzeneacetamide;Mabuprofene [INN-French];Mabuprofenum [INN-Latin];Mabuprofeno [INN-Spanish];UNII-02B8S6J90B;02B8S6J90B;Mabuprofen (INN);EINECS 280-048-9;ibuprofen aminoethanol;N-(beta-Hydroxyethyl)-dl-2-(4'-isobutylphenyl)propionamide;Benzeneacetamide, N-(2-hydroxyethyl)-alpha-methyl-4-(2-methylpropyl)-;(1)-N-(2-Hydroxyethyl)-2-(4-(2-methylpropyl)phenyl)propionamide;N-(2-Hydroxyethyl)-alpha-methyl-4-(2-methylpropyl)-benzeneacetamide;Aldospray analgesico (TN);MABUPROFEN [WHO-DD];SCHEMBL51633;MLS006011505;CHEMBL2105154;DTXSID90868676;CHEBI:135015;AKOS022173566;LS-28552;SMR004703282;D08153;EN300-6492972;(+-)-N-(2-Hydroxyethyl)-p-isobutylhydratropamide;A915590;SR-01000945195;SR-01000945195-1;Q27231513;Z1537048897;(+/-)-N-(2-HYDROXYETHYL)-P-ISOBUTYLHYDRATROPAMIDE;N-(2-hydroxyethyl)-2-[4-(2-methylpropyl)phenyl]propionamide;(+-)-N-(2-hydroxyethyl)-2-[4-(2-methylpropyl)phenyl]propionamide

Suppliers and Price of Mabuprofen

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Aminoprofen 95+%
1g
$ 446.00

Total 8 raw suppliers

Chemical Property of Mabuprofen

Chemical Property:

Vapor Pressure:1.02E-08mmHg at 25°C
Boiling Point:445.5°C at 760 mmHg
PKA:14.44±0.10(Predicted)
Flash Point:223.2°C
PSA：52.82000
Density:1.029g/cm³
LogP:2.93740
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:249.172878976
Heavy Atom Count:18
Complexity:245

Purity/Quality:

97% ^*data from raw suppliers

Aminoprofen 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)CC1=CC=C(C=C1)C(C)C(=O)NCCO
Description Aminoprofen, an amide of ibuprofen, is a topical anti-arthritic with analgesic properties. It is comparable to methyl salicylate in the carrageenan-induced paw edema and croton oil ear edema models, and is reported to be a superior analgesic.

Technology Process of Mabuprofen

There total 5 articles about Mabuprofen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 71381-91-4,114978-05-1,115588-20-0,34715-60-1
(+/-)-2-(4-isobutylphenyl)propanoyl chloride

: 141-43-5
ethanolamine

: 83394-44-9,82821-47-4
N-(2-hydroxyethyl)-2-(4-isobutylphenyl)propanamide

Guidance literature:: In dichloromethane; at 25 ℃; for 3h;
DOI:10.3109/14756366.2015.1088840

Reference yield:

: 41283-72-1
ibuprofen ethyl ester

: 141-43-5
ethanolamine

: 83394-44-9,82821-47-4
N-(2-hydroxyethyl)-2-(4-isobutylphenyl)propanamide

Guidance literature:: In dichloromethane; for 8h; Reflux;
DOI:10.1007/s00706-015-1557-x

Reference yield:

: 51146-57-7,58560-75-1
(R)-ibuprofene

: 83394-44-9,82821-47-4
N-(2-hydroxy-ethyl)-2-(4-isobutyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 3 h / Heating

2: 2.16 g / Et₃N / CH₂Cl₂ / 4 h

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm049082i