3-Phorbinepropionic acid, 21-carboxy-14-ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinyl-, dimethyl ester

Base Information

• Chemical Name: 3-Phorbinepropionic acid, 21-carboxy-14-ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinyl-, dimethyl ester
• CAS No.: 5594-30-9
• Molecular Formula: C36H38N4O5
• Molecular Weight: 606.722
• Mol file: 5594-30-9.mol

Synonyms:

Chemical Property of 3-Phorbinepropionic acid, 21-carboxy-14-ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinyl-, dimethyl ester

Chemical Property:

• Boiling Point: 952°Cat760mmHg
• Flash Point: 529.6°C
• Density: 1.3g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phorbinepropionic acid, 21-carboxy-14-ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinyl-, dimethyl ester

There total 35 articles about 3-Phorbinepropionic acid, 21-carboxy-14-ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinyl-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + pheophorbide A (15664-29-6,78964-31-5) → pheophorbide a methyl ester (5594-30-9)

Guidance literature:

In diethyl ether;

DOI:10.1111/j.1751-1097.2007.00092.x

Reference yield: 96.0%

methanol (67-56-1) + pheophytin a (603-17-8,47907-36-8,74984-11-5,74984-81-9,75598-38-8) → pheophorbide a methyl ester (5594-30-9)

Guidance literature:

With sulfuric acid; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm2005139

Reference yield: 95.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + pheophorbide-a (15664-29-6) → methylpheophorbide a (5594-30-9,64070-09-3,138812-88-1)

Guidance literature:

In methanol; diethyl ether; at 0 ℃; for 0.25h;

DOI:10.1016/S0968-0896(01)00305-4

upstream raw materials:

diazomethane

pheophorbide-a

methanol

pheophytin a

Downstream raw materials:

chlorin e6 trimethyl ester

Phytoporphyrin

methyl pyropheophorbide a

9,14-diethyl-3-(2-methoxycarbonyl-ethyl)-4,8,13,18-tetramethyl-20-oxo-3,4-didehydro-23H,25H-phorbine-21-carboxylic acid methyl ester

Refernces

• 1、 Smith, Kevin M.,Lai, Jan-Ji. "Syntheses of Heme d Models". . p. 5746 - 5748. Retrieved 1984.
• 2、 Shinozaki, Yoshinao,Richards, Gary,Ogawa, Keizo,Yamano, Akihito,Ohara, Kazuaki,Yamaguchi, Kentaro,Kawano, Shin-Ichiro,Tanaka, Kentaro,Araki, Yasuyuki,Wada, Takehiko,Otsuki, Joe. "Double helices of a pyridine-appended zinc chlorophyll derivative". . p. 5262 - 5265. Retrieved 2013.
• 3、 Kozyrev, Andrei,Ethirajan, Manivannan,Chen, Ping,Ohkubo, Kei,Robinson, Byron C.,Barkigia, Kathleen M.,Fukuzumi, Shunichi,Kadish, Karl M.,Pandey, Ravindra K.. "Synthesis, photophysical and electrochemistry of near-IR absorbing bacteriochlorins related to bacteriochlorophyll a". . p. 10260 - 10271. Retrieved 2012.
• 4、 Liu, Yang,Lee, Sang Hyeob,Lee, Woo Kyoung,Yoon, Il. "Ionic Liquid-dependent Gold Nanoparticles of Purpurin-18 for Cellular Imaging and Photodynamic Therapy In Vitro". . p. 230 - 233. Retrieved 2020/01/02.
• 5、 Doi,Tamiaki, Hitoshi. "Synthesis of a chlorophyll-a derivative fused with an additional exo-five-membered ring and its optical properties". . . Retrieved 2019/07/30.