N-(1,4-dioxonaphthalen-2-yl)benzamide

Base Information

Chemical Name:N-(1,4-dioxonaphthalen-2-yl)benzamide
CAS No.:65240-86-0
Molecular Formula:C17H11NO3
Molecular Weight:277.279
Hs Code.:
NSC Number:73233
DSSTox Substance ID:DTXSID80274449
Nikkaji Number:J738.755E
Wikidata:Q27088039
Pharos Ligand ID:LW3PD7WBF1SS
ChEMBL ID:CHEMBL1717890

Synonyms:alpha-benzoylamino-1,4-naphthoquinone;PPM 18;PPM-18

Suppliers and Price of N-(1,4-dioxonaphthalen-2-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Benzamido-1,4-naphthoquinone
100mg
$ 715.00

Matrix Scientific
N-(1,4-Dioxo-1,4-dihydronaphthalen-2-yl)benzamide 95%
25g
$ 4648.00

Matrix Scientific
N-(1,4-Dioxo-1,4-dihydronaphthalen-2-yl)benzamide 95%
5g
$ 1453.00

Cayman Chemical
PPM-18 ≥95%
1mg
$ 16.00

Cayman Chemical
PPM-18 ≥95%
25mg
$ 266.00

Cayman Chemical
PPM-18 ≥95%
5mg
$ 69.00

Cayman Chemical
PPM-18 ≥95%
10mg
$ 122.00

ApexBio Technology
PPM-18
10mg
$ 121.00

ApexBio Technology
PPM-18
5mg
$ 68.00

ApexBio Technology
PPM-18
25mg
$ 265.00

Total 9 raw suppliers

Chemical Property of N-(1,4-dioxonaphthalen-2-yl)benzamide

Chemical Property:

Vapor Pressure:8.15E-11mmHg at 25°C
Melting Point:134-136°C
Boiling Point:517.5°Cat760mmHg
Flash Point:208.2°C
PSA：63.24000
Density:1.35g/cm³
LogP:2.77040
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:277.07389321
Heavy Atom Count:21
Complexity:488

Purity/Quality:

≥95% ^*data from raw suppliers

2-Benzamido-1,4-naphthoquinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(=O)NC2=CC(=O)C3=CC=CC=C3C2=O
Uses 2-Benzamido-1,4-naphthoquinone belongs to a novel class of small molecule inhibitors of histone deacetylase (HDAC6), a family of enzymes that play significant role in numerous biological processes and diseases. 2-Benzamido-1,4-naphthoquinone was also shown to be an activation blocker of nuclear factor-kB (NF-kB).

Technology Process of N-(1,4-dioxonaphthalen-2-yl)benzamide

There total 8 articles about N-(1,4-dioxonaphthalen-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 495-18-1
Benzohydroxamic acid

: 130-15-4
[1,4]naphthoquinone

: 65240-86-0
N-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃; for 4h; Reagent/catalyst; Solvent;
DOI:10.1021/acs.orglett.6b02740