DIMETHYL 5-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-6,7-DICARBOXYLATE

Base Information

• Chemical Name: DIMETHYL 5-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-6,7-DICARBOXYLATE
• CAS No.: 60026-93-9
• Molecular Formula: C₁₇H₁₇NO₄
• Molecular Weight: 299.326
• Mol file: 60026-93-9.mol

Synonyms:3-phenyl-6,7-dihydro-5H-pyrrolizine-1,2-dicarboxylic acid dimethyl ester;dimethyl 5-phenyl-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate;

Chemical Property of DIMETHYL 5-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-6,7-DICARBOXYLATE

Chemical Property:

• PSA: 57.53000
• LogP: 2.67450

Purity/Quality:

99% ^*data from raw suppliers

Dimethyl 5-phenyl-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIMETHYL 5-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-6,7-DICARBOXYLATE

There total 11 articles about DIMETHYL 5-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-6,7-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

dimethyl acetylenedicarboxylate (762-42-5) + α-(2-oxo-1-pyrrolidinyl)phenylacetic acid (60729-82-0) → dimethyl 2,3-dihydro-5-phenyl-1H-pyrrolizine-6,7-dicarboxylate (60026-93-9)

Guidance literature:

With acetic anhydride; for 24h; Heating;

Reference yield: 72.0%

N-benzoylproline (195719-48-3) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 2,3-dihydro-5-phenyl-1H-pyrrolizine-6,7-dicarboxylate (60026-93-9)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In benzene; for 6h; Heating; further reagent silicon tetrachloride;

Reference yield: 62.0%

dimethyl acetylenedicarboxylate (762-42-5) + ethyl 2-diazo-3-oxo-3-(1-thiobenzoylpyrrolidin-2-yl)propionate (134926-98-0) → dimethyl 2,3-dihydro-5-phenyl-1H-pyrrolizine-6,7-dicarboxylate (60026-93-9)

Guidance literature:

With rhodium(II) octanoate; In benzene; for 3h; Heating;

DOI:10.3987/COM-92-S29

upstream raw materials:

N-benzoylproline

dimethyl acetylenedicarboxylate

ethyl 2-diazo-3-oxo-3-(1-thiobenzoylpyrrolidin-2-yl)propionate

α-(2-oxo-1-pyrrolidinyl)phenylacetic acid

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