N-[1-(4-hydroxy)butyl]indole-2-carboxamide

Base Information

• Chemical Name: N-[1-(4-hydroxy)butyl]indole-2-carboxamide
• CAS No.: 600709-74-8
• Molecular Formula: C13H16N2O2
• Molecular Weight: 232.28
• Mol file: 600709-74-8.mol

Synonyms:N-(4-Hydroxybutyl)-1H-indole-2-carboxamide;1H-Indole-2-carboxylic acid (4-hydroxy-butyl)-amide;N-[4-hydroxybutyl]indole-2-carboxamide;N-[1-(4-hydroxy)butyl]indole-2-carboxamide;N2-(4-butanol)-1H-2-indolecarboxamide;

Chemical Property of N-[1-(4-hydroxy)butyl]indole-2-carboxamide

Chemical Property:

• Melting Point: 108 - 109 °C (methanol)
• PSA: 65.12000
• LogP: 2.06110

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-(4-hydroxy)butyl]indole-2-carboxamide

There total 1 articles about N-[1-(4-hydroxy)butyl]indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Indole-2-carboxylic acid (1477-50-5,1228050-17-6) + 4-Aminobutanol (13325-10-5) → N-[1-(4-hydroxy)butyl]indole-2-carboxamide (600709-74-8)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/acs.jmedchem.6b01875

Reference yield:

N-[1-(4-hydroxy)butyl]indole-2-carboxamide (600709-74-8) → JJC 7-082

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / triphenylphosphine; carbon tetrabromide / acetonitrile / 20 °C

2: 48 percent / triethylamine / acetonitrile / Heating

With carbon tetrabromide; triethylamine; triphenylphosphine; In acetonitrile;

DOI:10.1021/jm0211220

Reference yield:

N-[1-(4-hydroxy)butyl]indole-2-carboxamide (600709-74-8) → 1H-Indole-2-carboxylic acid {4-[4-(2,4-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / triphenylphosphine; carbon tetrabromide / acetonitrile / 20 °C

2: 65 percent / triethylamine / acetonitrile / Heating

With carbon tetrabromide; triethylamine; triphenylphosphine; In acetonitrile;

DOI:10.1021/jm0211220

upstream raw materials:

Indole-2-carboxylic acid

4-Aminobutanol

Downstream raw materials:

C₃₁H₂₈N₂O₂S