4-Amino-1-butanol

Base Information

• Chemical Name: 4-Amino-1-butanol
• CAS No.: 13325-10-5
• Molecular Formula: C4H11NO
• Molecular Weight: 89.1374
• Hs Code.: 2922.19 Oral rat LD50: 1150mg/kg
• European Community (EC) Number: 236-364-4
• DSSTox Substance ID: DTXSID70158027
• Nikkaji Number: J50.239A
• Wikidata: Q63392130
• Mol file: 13325-10-5.mol

Synonyms:4-aminobutanol

Chemical Property of 4-Amino-1-butanol

Chemical Property:

• Appearance/Colour: Very light clear yellow liquid
• Vapor Pressure: 0.0575mmHg at 25°C
• Melting Point: 16-18 °C(lit.)
• Refractive Index: n20/D ~1.462(lit.)
• Boiling Point: 206 °C at 760 mmHg
• PKA: 15.10±0.10(Predicted)
• Flash Point: 107.8 °C
• PSA: 46.25000
• Density: 0.931 g/cm³
• LogP: 0.41790
• Storage Temp.: Store at R.T.
• Sensitive.: Air Sensitive & Hygroscopic
• Water Solubility.: MISCIBLE
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 89.084063974
• Heavy Atom Count: 6
• Complexity: 23.5

Purity/Quality:

98% ^*data from raw suppliers

4-Amino-1-butanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 26-36/37/39-45-25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CCO)CN
• Uses: 4-Amino-1-butanol is a useful intermediate in a variety of organic synthesis. It is mainly used in personal-care products, preparation of water soluble cationic flocculants and ion exchange resins as well as in the preparation of beta-lactam antibiotics. It is used for the production of efficient anionic emulsifiers, nonionic polyethylene emulsions, water treatment, metal treatment and absorption of carbon dioxide gas. It is used as a pigment dispersion aid and curing agent in selected textile -resins. 4-Amino-1-butanol was used:As a linker in the synthesis of highly branched poly(β-amino esters)(HPAEs) for gene delivery.As a side chain to modulate antimicrobial and hemolytic activities of copolymers.In the total synthesis of (+)-fawcettimine,(+)-fawcettidine, and (?)-lycojapodine A.

Technology Process of 4-Amino-1-butanol

There total 34 articles about 4-Amino-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(4-acetyloxybutyl)phthalimide (7606-22-6) → 4-Aminobutanol (13325-10-5)

Guidance literature:

With weakly basic anion exchange resin (DIAION WA-20); water; In ethanol; for 1h; Heating;

DOI:10.1055/s-1990-27000

Reference yield:

ethanol (64-17-5) + sodium ethanolate (141-52-6) + 2-iminotetrahydrofuran hydrochloride (2453-49-8) → 4-Aminobutanol (13325-10-5)

Guidance literature:

Hydrieren des Reaktionsprodukts;

Reference yield:

ethene (74-85-1) → 4-Aminobutanol (13325-10-5)

Guidance literature:

With hydrogenchloride; vanadium(III) sulfate; hydroxylamine hydrochloride;

DOI:10.1021/ja01515a052

upstream raw materials:

ethanol

sodium ethanolate

2-iminotetrahydrofuran hydrochloride

ethene

Downstream raw materials:

hexahydro-[1,3]oxazepine

4-hexahydroazepin-1-yl-butan-1-ol

pyrrolidine

4-amino-n-butyric acid