Methyl 5-amino-3-methylthiophene-2-carboxylate

Base Information

Chemical Name:Methyl 5-amino-3-methylthiophene-2-carboxylate
CAS No.:602310-67-8
Molecular Formula:C7H9NO2S
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID80427852
Wikidata:Q82240566

Synonyms:methyl 5-amino-3-methylthiophene-2-carboxylate;602310-67-8;2-Thiophenecarboxylic acid, 5-amino-3-methyl-, methyl ester;SCHEMBL381164;DTXSID80427852;MFCD07366353;AKOS000280723;AS-70855;CS-0047261;EN300-40746;methyl5-amino-3-methylthiophene-2-carboxylate;W15346

Suppliers and Price of Methyl 5-amino-3-methylthiophene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Methyl 5-amino-3-methylthiophene-2-carboxylate

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:171.03539970
Heavy Atom Count:11
Complexity:163

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(SC(=C1)N)C(=O)OC

Technology Process of Methyl 5-amino-3-methylthiophene-2-carboxylate

There total 4 articles about Methyl 5-amino-3-methylthiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 956118-35-7
3-methyl-5-nitro-thiophene-2-carboxylic acid methyl ester

: 602310-67-8
methyl 5-amino-3-methylthiophene-2-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; at 20 ℃; for 24h;

Reference yield: 61.0%

: 372-09-8
cyanoacetic acid

: 105-45-3
acetoacetic acid methyl ester

: 602310-67-8
methyl 5-amino-3-methylthiophene-2-carboxylate

Guidance literature:: cyanoacetic acid; acetoacetic acid methyl ester; With ammonium acetate; acetic acid; In toluene; for 31h; Reflux;

With sodium hydrogencarbonate; In water; toluene;

With sulfur; diethylamine; In ethanol; at 20 ℃; for 36h;

Reference yield:

: 23806-24-8
3-methyl-2-thiophenecarboxylic acid

: 602310-67-8
methyl 5-amino-3-methylthiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 60 °C

2: sulfuric acid; nitric acid

3: hydrogen / palladium on activated charcoal / 24 h / 20 °C

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal;