Chemical Property of 6-Chlorouracil
Chemical Property:
- Appearance/Colour:White powder
- Vapor Pressure:1.48E-05mmHg at 25°C
- Melting Point:290-295 °C
- Refractive Index:1.635
- Boiling Point:300 °C
- PKA:6.24±0.10(Predicted)
- Flash Point:182°C
- PSA：65.72000
- Density:1.61 g/cm3
- LogP:-0.28340
- Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
- Solubility.:Soluble in Ammonium Hydroxide
- Water Solubility.:4.885g/L(25 oC)
- XLogP3:-0.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:0
- Exact Mass:145.9883050
- Heavy Atom Count:9
- Complexity:199
- Purity/Quality:
-
99%, *data from raw suppliers
6-Chlorouracil *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=C(NC(=O)NC1=O)Cl
-
Uses
6-Chlorouracil acts as an inhibitor of yeast alcohol dehydrogenase (ADH-H). 6-Chlorouracil is a potential inhibitor of DNA repair glycosylases. Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.
