4-Chloro-2,6-dimethoxypyrimidine

Base Information

• Chemical Name: 4-Chloro-2,6-dimethoxypyrimidine
• CAS No.: 6320-15-6
• Molecular Formula: C6H7 Cl N2 O2
• Molecular Weight: 174.587
• Hs Code.: 29335995
• European Community (EC) Number: 228-669-6
• NSC Number: 31796
• DSSTox Substance ID: DTXSID60212561
• Nikkaji Number: J149.396E
• Mol file: 6320-15-6.mol

Synonyms:4-Chloro-2,6-dimethoxypyrimidine;6320-15-6;6-Chloro-2,4-dimethoxypyrimidine;2,4-Dimethoxy-6-chloropyrimidine;Pyrimidine, 4-chloro-2,6-dimethoxy-;C6H7ClN2O2;EINECS 228-669-6;MFCD00006068;4-chloro-2,6-dimethoxy-pyrimidine;NSC31796;NSC 31796;SCHEMBL105629;4-Chlor-2,6-dimethoxypyrimidin;4-chloro-2,6-dimethoxypyrimidin;DTXSID60212561;2,6-dimethoxy-4-chloropyrimidine;6-Chloro-2,4-dimethixypyrimidine;6-chloro-2,4-dimethoxy-pyrimidine;AC1917;NSC-31796;AKOS015852349;AB00578;RS-1011;6-Chloro-2,4-dimethoxypyrimidine, 99%;AC-24776;SY040739;CS-0137521;D1385;FT-0618004;EN300-129388

Chemical Property of 4-Chloro-2,6-dimethoxypyrimidine

Chemical Property:

• Appearance/Colour: white powder or flakes.
• Vapor Pressure: 0.00637mmHg at 25°C
• Melting Point: 74-76 °C(lit.)
• Refractive Index: 1.51
• Boiling Point: 280.6 °C at 760 mmHg
• PKA: -1.92±0.30(Predicted)
• Flash Point: 123.5 °C
• PSA: 44.24000
• Density: 1.285 g/cm³
• LogP: 1.14720
• Storage Temp.: -20°C
• Sensitive.: Hygroscopic
• Solubility.: Soluble in chloroform, ethyl acetate and methanol.
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 174.0196052
• Heavy Atom Count: 11
• Complexity: 125

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-2,6-dimethoxypyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=NC(=N1)OC)Cl
• Uses: It is used in the synthesis of silyl and stannyl pyrimidines.

Technology Process of 4-Chloro-2,6-dimethoxypyrimidine

There total 5 articles about 4-Chloro-2,6-dimethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

2,4,6-trichloropyrimidine (3764-01-0) + sodium methylate (124-41-4) → 6-chloro-2,4-dimethoxypyrimidine (6320-15-6)

Guidance literature:

In methanol; at 0 - 20 ℃; for 3.5h;

Reference yield:

2,6-dimethoxy-pyrimidine-4-sulfonic acid (71885-70-6) → 6-chloro-2,4-dimethoxypyrimidine (6320-15-6)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate;

DOI:10.1021/ja01652a056

Reference yield:

sodium methylate (124-41-4) + 4,6-dichloro-2-methoxypyrimidine (1074-40-4) → 6-chloro-2,4-dimethoxypyrimidine (6320-15-6)

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1002/(SICI)1096-9063(199606)47:2<103::AID-PS396>3.0.CO;2-Z

upstream raw materials:

2,4,6-trichloropyrimidine

sodium methylate

2,4-dichloro-6-methoxypyrimidine

2,6-dimethoxy-pyrimidine-4-sulfonic acid

Downstream raw materials:

Trimethyl-4-(2,6-dimethoxypyrimidinyl)ammoniumchlorid

1,3-Dimethyl-6-chlorouracil

6-chlorouracil

2,6-dimethoxypyrimidin-4-amine