Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-

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Chemical Name:Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-
CAS No.:603125-49-1
Molecular Formula:C₃₀H₃₂ClNO₅
Molecular Weight:522.041
Hs Code.:

Synonyms:

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Chemical Property of Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-

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Technology Process of Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]-

There total 11 articles about Benzoic acid, 3-[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603122-30-1
3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoic acid methyl ester

: 603125-49-1
C₃₀H₃₂ClNO₅

Guidance literature:: With methanol; sodium hydroxide; water; at 20 ℃;
DOI:10.1021/jm800222k

Reference yield:

: 603125-59-3
(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 603125-49-1
C₃₀H₃₂ClNO₅

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 2 h / 20 - 80 °C / Inert atmosphere

2: methanol; sodium hydroxide; water / 20 °C

With methanol; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; In water; 1: Suzuki coupling;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 603125-49-1
C₃₀H₃₂ClNO₅

Guidance literature:: Multi-step reaction with 7 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 2 h / 20 - 80 °C / Inert atmosphere

7: methanol; sodium hydroxide; water / 20 °C

With 2,6-dimethylpyridine; methanol; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; boron tribromide; sodium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 6: Suzuki coupling;
DOI:10.1021/jm800222k