Technology Process of Boronic acid,
[4-[(4S,5R)-4-(fluoromethyl)-4,5-dihydro-2-phenyl-5-oxazolyl]phenyl]-
There total 3 articles about Boronic acid,
[4-[(4S,5R)-4-(fluoromethyl)-4,5-dihydro-2-phenyl-5-oxazolyl]phenyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-fluoromethyl-5-(4-iodo-phenyl)-2-phenyl-4,5-dihydro-oxazole;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Triisopropyl borate;
In
tetrahydrofuran; hexane;
at 20 ℃;
-
-
119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0
(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C
3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
3.2: 0 - 20 °C
4.1: sulfuric acid / 18 h / 105 °C
4.2: 20 °C / pH 13
5.1: triethylamine / 1,1-dichloroethane / Reflux
6.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C
7.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
7.2: 20 °C
With
hydrogenchloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; hydrogen; sodium hydrogencarbonate; triethylamine; sodium nitrite;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1,1-dichloroethane; hexane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C
2.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: sulfuric acid / 18 h / 105 °C
3.2: 20 °C / pH 13
4.1: triethylamine / 1,1-dichloroethane / Reflux
5.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C
6.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
6.2: 20 °C
With
hydrogenchloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; hydrogen; triethylamine; sodium nitrite;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1,1-dichloroethane; hexane; dichloromethane; water;
