5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine

Base Information

Chemical Name:5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine
CAS No.:1400741-16-3
Molecular Formula:C₂₁H₁₈FN₃O
Molecular Weight:347.392
Hs Code.:

Synonyms:5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine

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Chemical Property of 5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine

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Technology Process of 5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine

There total 9 articles about 5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1072-97-5
5-bromo-2-pyridylamine

: 605647-75-4
4-fluoromethyl-2-phenyl-5-[4-(dihydroxyboronyl)-phenyl]-4,5-dihydro-oxazole

: 1400741-16-3
5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 90 ℃; Inert atmosphere;

Reference yield:

: 119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0
(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

: 1400741-16-3
5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

3.2: 0 - 20 °C

4.1: sulfuric acid / 18 h / 105 °C

4.2: 20 °C / pH 13

5.1: triethylamine / 1,1-dichloroethane / Reflux

6.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

7.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

7.2: 20 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 90 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; toluene; 8.1: Suzuki Coupling;

Reference yield:

: 5333-86-8
ethyl benzimidate hydrochloride

: 1400741-16-3
5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,1-dichloroethane / Reflux

2.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 90 °C / Inert atmosphere

With n-butyllithium; diethylamino-sulfur trifluoride; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; toluene; 4.1: Suzuki Coupling;