Acetic acid, ((7-amino-(1,2,4)triazolo(1,5-c)pyrimidin-5-yl)thio)-, hydrazide

Base Information

• Chemical Name: Acetic acid, ((7-amino-(1,2,4)triazolo(1,5-c)pyrimidin-5-yl)thio)-, hydrazide
• CAS No.: 143212-84-4
• Molecular Formula: C₇H₉N₇OS
• Molecular Weight: 239.261
• DSSTox Substance ID: DTXSID20162356
• Nikkaji Number: J503.315B
• Wikidata: Q83031009
• Mol file: 143212-84-4.mol

Synonyms:BRN 5821800;Acetic acid, ((7-amino-(1,2,4)triazolo(1,5-c)pyrimidin-5-yl)thio)-, hydrazide;(7-Amino-s-triazolo(1,5-c)pyrimidyl-5)thioacetic acid hydrazide;2-[(7-amino[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)thio]acetohydrazide;((7-Amino-(1,2,4)triazolo(1,5-c)pyrimidin-5-yl)thio)acetic acid hydrazide;143212-84-4;DTXSID20162356;C7-H9-N7-O-S;STL445894;AKOS005220662;2-[(7-amino[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)sulfanyl]acetohydrazide

Chemical Property of Acetic acid, ((7-amino-(1,2,4)triazolo(1,5-c)pyrimidin-5-yl)thio)-, hydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.94g/cm³
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 239.05892911
• Heavy Atom Count: 16
• Complexity: 265

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(N2C1=NC=N2)SCC(=O)NN)N

Technology Process of Acetic acid, ((7-amino-(1,2,4)triazolo(1,5-c)pyrimidin-5-yl)thio)-, hydrazide

There total 2 articles about Acetic acid, ((7-amino-(1,2,4)triazolo(1,5-c)pyrimidin-5-yl)thio)-, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl (7-amino-s-triazole<1,5-c>pyrimidyl-5)thioacetate (143212-80-0) → (7-amino-s-triazole<1,5-c>yrimidyl-5)thioacetic acid hydrazide (143212-84-4)

Guidance literature:

With hydrazine; In diethyl ether; ethanol; water; for 0.5h; Ambient temperature;

DOI:10.1007/BF00766451

Reference yield:

7-Amino<1,2,4>triazolo<1,5-c>pyrimidine-5(6H)-thione (70182-88-6) → (7-amino-s-triazole<1,5-c>yrimidyl-5)thioacetic acid hydrazide (143212-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / EtONa / ethanol / 3 h / Heating

2: 90 percent / H₂NNH₂ / ethanol; H₂O; diethyl ether / 0.5 h / Ambient temperature

With sodium ethanolate; hydrazine; In diethyl ether; ethanol; water;

DOI:10.1007/BF00766451

Reference yield: 76.0%

salicylaldehyde (90-02-8) + (7-amino-s-triazole<1,5-c>yrimidyl-5)thioacetic acid hydrazide (143212-84-4) → (7-Amino-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylsulfanyl)-acetic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (143212-86-6)

Guidance literature:

In ethanol; water; for 2h; Heating;

DOI:10.1007/BF00766451

upstream raw materials:

ethyl (7-amino-s-triazole<1,5-c>pyrimidyl-5)thioacetate

7-Amino<1,2,4>triazolo<1,5-c>pyrimidine-5(6H)-thione

Downstream raw materials:

(7-Amino-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylsulfanyl)-acetic acid [(Z)-2-bromo-3-phenyl-prop-2-en-(E)-ylidene]-hydrazide

(7-Amino-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylsulfanyl)-acetic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide

(7-Amino-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylsulfanyl)-acetic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide