(3R,6S)-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione

Base Information

Chemical Name:(3R,6S)-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione
CAS No.:61139-44-4
Molecular Formula:C₂₀H₂₂N₂O₂
Molecular Weight:322.407
Hs Code.:
ChEMBL ID:CHEMBL91198
DSSTox Substance ID:DTXSID00483117
Nikkaji Number:J1.607.236B
Wikidata:Q82320143

Synonyms:61139-44-4;CHEMBL91198;(3R,6S)-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione;DTXSID00483117

Suppliers and Price of (3R,6S)-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (3R,6S)-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:322.168127949
Heavy Atom Count:24
Complexity:411

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C(C(=O)N(C(C1=O)CC2=CC=CC=C2)C)CC3=CC=CC=C3
Isomeric SMILES:CN1[C@@H](C(=O)N([C@H](C1=O)CC2=CC=CC=C2)C)CC3=CC=CC=C3

Technology Process of (3R,6S)-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione

There total 7 articles about (3R,6S)-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 94514-45-1
1,4-dimethyl-(Z)-3-(Z)-6-dibenzylidene-2,5-piperazinedione

: 13795-55-6,61125-52-8,61139-44-4,94595-82-1
(+/-)-cis-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 16h;
DOI:10.1071/CH9842397

Reference yield: 89.0%

: 15136-18-2,374674-82-5
(+/-)-trans-3,6-dibenzylpiperazine-2,5-dione

: 74-88-4
methyl iodide

: 61139-44-4,374674-79-0
cyclo-L-N-methylphenylalanyl-D-N-methylphenylalanyl

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00524-8

Reference yield:

: 74720-33-5
(Z)-3-(Z)-6-dibenzylidene-2,5-piperazinedione

: 13795-55-6,61125-52-8,61139-44-4,94595-82-1
(+/-)-cis-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 10percent aq. NaOH / ethanol / 3 h / Ambient temperature

2: 96 percent / H₂ / 10percent Pd/C / acetic acid / 16 h

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; acetic acid;
DOI:10.1071/CH9842397