1-(4-(2-(2-Phenylethyl)phenoxy)butyl)-4-piperidinecarboxamide

Base Information

Chemical Name:1-(4-(2-(2-Phenylethyl)phenoxy)butyl)-4-piperidinecarboxamide
CAS No.:72278-97-8
Molecular Formula:C24H32 N2 O2
Molecular Weight:380.52
Hs Code.:
DSSTox Substance ID:DTXSID10222594
Nikkaji Number:J322.402C
Wikidata:Q83100880
ChEMBL ID:CHEMBL54721
Mol file:72278-97-8.mol

Synonyms:72278-97-8;1-(4-(2-(2-Phenylethyl)phenoxy)butyl)-4-piperidinecarboxamide;2-(4-(4-Carbamoylpiperidino)butoxy)bibenzyl;4-Piperidinecarboxamide, 1-(4-(2-(2-phenylethyl)phenoxy)butyl)-;CHEMBL54721;SCHEMBL11259036;DTXSID10222594;1-[4-[2-(2-phenylethyl)phenoxy]butyl]piperidine-4-carboxamide;LS-114582

Suppliers and Price of 1-(4-(2-(2-Phenylethyl)phenoxy)butyl)-4-piperidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(4-(2-(2-PHENYLETHYL)PHENOXY)BUTYL)-4-PIPERIDINECARBOXAMIDE 95.00%
5MG
$ 500.89

Total 2 raw suppliers

Chemical Property of 1-(4-(2-(2-Phenylethyl)phenoxy)butyl)-4-piperidinecarboxamide

Chemical Property:

Vapor Pressure:1.64E-12mmHg at 25°C
Boiling Point:558.6°C at 760 mmHg
Flash Point:291.6°C
PSA：56.55000
Density:1.092g/cm³
LogP:4.91570
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:10
Exact Mass:380.246378268
Heavy Atom Count:28
Complexity:442

Purity/Quality:: 1-(4-(2-(2-PHENYLETHYL)PHENOXY)BUTYL)-4-PIPERIDINECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C(=O)N)CCCCOC2=CC=CC=C2CCC3=CC=CC=C3

Technology Process of 1-(4-(2-(2-Phenylethyl)phenoxy)butyl)-4-piperidinecarboxamide

There total 6 articles about 1-(4-(2-(2-Phenylethyl)phenoxy)butyl)-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 39546-32-2
4-carboxamidopiperidine

: 72279-14-2
2-(4-bromobutoxy)-1-(2-phenylethyl)benzene

: 72278-97-8
<2-<2-<4-(4-carbamoylpiperidino)butoxy>phenyl>ethyl>benzene

Guidance literature:: With triethylamine; In tetrahydrofuran; water; at 70 ℃; for 10h;
DOI:10.1021/jm00168a043

Reference yield:

: 18493-15-7,42224-48-6,3839-69-8
2-[(E/Z)-2-phenylvinyl]phenol

: 72278-97-8
<2-<2-<4-(4-carbamoylpiperidino)butoxy>phenyl>ethyl>benzene

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 5percent Pd/C / ethanol / 20 h

2: 90.8 percent / KOH / H₂O; 2-methyl-propan-2-ol / 2 h / Heating

3: 71 percent / Et₃N / tetrahydrofuran; H₂O / 10 h / 70 °C

With potassium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; tert-butyl alcohol;
DOI:10.1021/jm00168a043

Reference yield:

: 13246-50-9
benzylchlorotriphenylphosphorane

: 72278-97-8
<2-<2-<4-(4-carbamoylpiperidino)butoxy>phenyl>ethyl>benzene

Guidance literature:: Multi-step reaction with 4 steps

1: DBU / acetonitrile / 4 h / Heating

2: H₂ / 5percent Pd/C / ethanol / 20 h

3: 90.8 percent / KOH / H₂O; 2-methyl-propan-2-ol / 2 h / Heating

4: 71 percent / Et₃N / tetrahydrofuran; H₂O / 10 h / 70 °C

With potassium hydroxide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm00168a043