5-FLUORO-2-PHENOXYANILINE

Base Information

• Chemical Name: 5-FLUORO-2-PHENOXYANILINE
• CAS No.: 613662-01-4
• Molecular Formula: C12H10FNO
• Molecular Weight: 203.216
• Mol file: 613662-01-4.mol

Synonyms:Fluorooxindole;5-fluoro-2-phenoxy-aniline;5-fluoro-2-oxo-1,2-dihydro-indole;5-Fluorooxindole;5-fluoro-1,3-dihydro-indol-2-one;5-Fluoroindole-2-One;5-FLUORO-2-OXYINDOLE;5-FLUROOXINDOLE;5-fluoroindolin-2-one;5-Fluoro-2-indolinone;5-fluoro-2-phenoxy-phenylamine;

Chemical Property of 5-FLUORO-2-PHENOXYANILINE

Chemical Property:

• PSA: 35.25000
• LogP: 3.78140

Purity/Quality:

98%min ^*data from raw suppliers

5-fluoro-2-phenoxyaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-2-PHENOXYANILINE

There total 5 articles about 5-FLUORO-2-PHENOXYANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-fluoro-2-nitro-1-phenoxybenzene (613662-00-3) → 5-fluoro-2-phenoxyaniline (613662-01-4)

Guidance literature:

With tin(ll) chloride; In ethanol; at 40 ℃; for 2.5h;

Reference yield:

1,4-difluoro-2-nitrobenzene (364-74-9) → 5-fluoro-2-phenoxyaniline (613662-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 3 h / 80 °C

2: Fe; NH₄Cl / ethanol; H₂O / 5 h / 80 °C

With iron; potassium carbonate; ammonium chloride; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm061127n

Reference yield:

phenol (108-95-2,27073-41-2) → 5-fluoro-2-phenoxyaniline (613662-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / K₂CO₃ / dimethylformamide / 3 h / 75 °C

2: H₂ / PtO₂ / methanol / 4.5 h / 50 °C

With hydrogen; potassium carbonate; platinum(IV) oxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2003.10.050

upstream raw materials:

4-fluoro-2-nitro-1-phenoxybenzene

1,4-difluoro-2-nitrobenzene

phenol

Downstream raw materials:

C₂₁H₁₈F₂N₂O₃

C₂₃H₂₁BrFNO₄

C₂₁H₁₈BrFN₂O₃

C₂₃H₂₁F⁽¹⁸⁾FNO₄

Refernces

• 1、 Wang, Min,Gao, Mingzhang,Hutchins, Gary D.,Zheng, Qi-Huang. "Synthesis of [11C]FEDAA1106 as a new PET imaging probe of peripheral benzodiazepine receptor expression". experimental part. p. 2748 - 2753. Retrieved 2009/09/25.
• 2、 Rahman, Obaidur,Langstroem, Bengt. "Synthesis of N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)[carbonyl- 11C]acetamide ([carbonyl- 11C]DAA1106) and analogues using [11C]carbon monoxide and palladium(0) complex". . p. 1192 - 1199. Retrieved 2008/04/05.