Benzeneacetic acid, a-[(4-chlorobenzoyl)amino]-, 3-methyl-2-butenyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-[(4-chlorobenzoyl)amino]-, 3-methyl-2-butenyl ester
• CAS No.: 62046-01-9
• Molecular Formula: C20H20ClNO3
• Molecular Weight: 357.837
• Mol file: 62046-01-9.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-[(4-chlorobenzoyl)amino]-, 3-methyl-2-butenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, a-[(4-chlorobenzoyl)amino]-, 3-methyl-2-butenyl ester

There total 2 articles about Benzeneacetic acid, a-[(4-chlorobenzoyl)amino]-, 3-methyl-2-butenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-chloro-benzoylamino)-phenyl-acetic acid methyl ester (62045-89-0) → (4-chloro-benzoylamino)-phenyl-acetic acid 3-methyl-but-2-enyl ester (62046-01-9)

Guidance literature:

alkylation;

DOI:10.1021/ja00267a036

Reference yield:

Acetylamino-phenyl-acetic acid methyl ester; compound with dicyclohexyl-amine + prenyl bromide (870-63-3) + para-chlorobenzoic acid (74-11-3) → (4-chloro-benzoylamino)-phenyl-acetic acid 3-methyl-but-2-enyl ester (62046-01-9)

Guidance literature:

Multistep reaction; (i), (ii) /BRN= 1420778/, NaH, molecular sieves, THF;

Reference yield:

(4-chloro-benzoylamino)-phenyl-acetic acid 3-methyl-but-2-enyl ester (62046-01-9) → phenylglycin (2835-06-5)

Guidance literature:

Multi-step reaction with 3 steps

1: PPh₃/NEt₃ / hexachloroethane

2: NaBH₄ / tetrahydrofuran; methanol / 3 h / 25 °C

3: 20percent citric acid/ phloroglycine-dihydrate / dioxane / Heating

With sodium tetrahydroborate; phloroglycine-dihydrate; triethylamine; triphenylphosphine; citric acid; In tetrahydrofuran; 1,4-dioxane; methanol; hexachloroethane;

upstream raw materials:

prenyl bromide

para-chlorobenzoic acid

(4-chloro-benzoylamino)-phenyl-acetic acid methyl ester

Downstream raw materials:

2-(4-chlorophenyl)-2-(3,3-dimethylallyl)-4-phenyl-5(2H)-oxazolone

1-(p-chlorophenyl)-4-methyl-3-penten-1-one

phenylglycin

1-(4-Chloro-phenyl)-4-methyl-pent-3-en-1-ol