2-CYANO-3-PHENYLPROPIONIC ACID

Base Information

• Chemical Name: 2-CYANO-3-PHENYLPROPIONIC ACID
• CAS No.: 5331-42-0
• Molecular Formula: C10H9 N O2
• Molecular Weight: 175.187
• Hs Code.: 2926909090
• Mol file: 5331-42-0.mol

Synonyms:Hydrocinnamicacid, a-cyano- (7CI,8CI); (?à)-2-Cyano-3-phenylpropanoic acid;2-Cyano-3-phenylpropionic acid; NSC 2286; a-Cyanobenzenepropanoic acid

Chemical Property of 2-CYANO-3-PHENYLPROPIONIC ACID

Chemical Property:

• Vapor Pressure: 9.97E-06mmHg at 25°C
• Boiling Point: 357.4°C at 760 mmHg
• Flash Point: 169.9°C
• PSA: 61.09000
• LogP: 1.45348
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Cyano-3-phenylpropionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CYANO-3-PHENYLPROPIONIC ACID

There total 12 articles about 2-CYANO-3-PHENYLPROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl 2-cyano-3-phenylpropanoate (6731-58-4) → 2-cyano-3-phenylpropionic acid (5331-42-0)

Guidance literature:

With Dowex-50; In water; for 12h; Heating;

Reference yield:

cinnamic nitrile (1885-38-7) + carbon dioxide (124-38-9,18923-20-1) → 2-cyano-3-phenylpropionic acid (5331-42-0)

Guidance literature:

With diethylzinc; cobalt acetylacetonate; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 4h; Schlenk technique;

DOI:10.1246/cl.131163

Reference yield:

ethyl 2-cyano-3-phenylpropanoate (6731-58-4) + 2N-hydrochloric acid → 2-cyano-3-phenylpropionic acid (5331-42-0)

Guidance literature:

With sodium hydroxide; In ethanol; water;

upstream raw materials:

ethyl 2-cyano-3-phenylpropanoate

2-cyano-3-phenylacrylic acid

water

benzyl chloride

Downstream raw materials:

3-phenyl-2-phenylhydrazono-propionitrile

3-phenyl-2-p-tolylhydrazono-propionitrile

2-cyano-3-phenyl-propionyl chloride

dihydrocinnamonitrile