2-Chloro-7-(MethoxyMethoxy)-10H-phenothiazine

Base Information

• Chemical Name: 2-Chloro-7-(MethoxyMethoxy)-10H-phenothiazine
• CAS No.: 62835-54-5
• Molecular Formula: C14H12ClNO2S
• Molecular Weight: 293.76900
• Mol file: 62835-54-5.mol

Synonyms:2-Chloro-7-(methoxymethoxy)-10H-phenothiazine;

Chemical Property of 2-Chloro-7-(MethoxyMethoxy)-10H-phenothiazine

Chemical Property:

• PSA: 55.79000
• LogP: 4.66890

Purity/Quality:

2-Chloro-7-(methoxymethoxy)-10H-phenothiazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-7-(methoxymethoxy)-10H-phenothiazine is a building block that has been used for the preparation of ?7-Hydroxydemethylprochlorperazine and 7-hydroxychlorpromazine.

Technology Process of 2-Chloro-7-(MethoxyMethoxy)-10H-phenothiazine

There total 1 articles about 2-Chloro-7-(MethoxyMethoxy)-10H-phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-chloro-10H-phenothiazin-3-ol (2002-32-6) + chloromethyl methyl ether (107-30-2) → 2-chloro-7-methoxymethoxy-10H-phenothiazine (62835-54-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570140121

Reference yield:

3-(N-methylpiperazinyl)propyl chloride (104-16-5) + 2-chloro-7-methoxymethoxy-10H-phenothiazine (62835-54-5) → 7-Hydroxyprochlorperazin (52172-19-7)

Guidance literature:

Multistep reaction; (i) NaH, DMSO, (ii) /BRN= 106074/, (iii) HCl, MeOH;

DOI:10.1002/jhet.5570140121

Reference yield:

piperazine (110-85-0) + 2-chloro-7-methoxymethoxy-10H-phenothiazine (62835-54-5) + 1.3-chlorobromopropane (109-70-6) → 7-Hydroxydesmethylprochlorperazin (62835-68-1)

Guidance literature:

Multistep reaction; (i) NaH, DMSO, (ii) /BRN= 605278/, (iii) /BRN= 102555/, KI, butanone, (iv) HCl, MeOH;

DOI:10.1002/jhet.5570140121

upstream raw materials:

8-chloro-10H-phenothiazin-3-ol

chloromethyl methyl ether

Downstream raw materials:

7-Hydroxydesmethylprochlorperazin

7-Hydroxyperphenazin

7-Hydroxyprochlorperazin

Refernces