3-Methylbutyl Chloroformate

Base Information

• Chemical Name: 3-Methylbutyl Chloroformate
• CAS No.: 628-50-2
• Molecular Formula: C6H11ClO2
• Molecular Weight: 150.605
• Mol file: 628-50-2.mol

Synonyms:1-chlorocarbonyloxy-3-methyl-butane;Kohlensaeure-chlorid-isopentylester;Chlorokohlensaeure-isopentylester;Carbonochloridic acid, 3-methylbutyl ester;carbonochloridic acid 3-methyl-butyl ester;chlorocarbonic acid isopentyl ester;isoamyl chloroformate;

Chemical Property of 3-Methylbutyl Chloroformate

Chemical Property:

• Refractive Index: 1.4176
• Boiling Point: 207.14°C (rough estimate)
• PSA: 26.30000
• Density: 1.0288
• LogP: 2.40790

Purity/Quality:

99% ^*data from raw suppliers

3-MethylbutylChloroformate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Methylbutyl Chloroformate

There total 7 articles about 3-Methylbutyl Chloroformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.7%

i-Amyl alcohol (123-51-3) + bis(trichloromethyl) carbonate (32315-10-9) → carbonochloridic acid 3-methyl-butyl ester (628-50-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

i-Amyl alcohol (123-51-3) + 7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-1-(hydroxymethyl)-3,4-dihydroquinolin-2-(1H )-one (1259312-25-8) → carbonochloridic acid 3-methyl-butyl ester (628-50-2)

Guidance literature:

i-Amyl alcohol; With phosgene; In tetrahydrofuran; toluene; for 5h;

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-1-(hydroxymethyl)-3,4-dihydroquinolin-2-(1H )-one; With pyridine; dmap; triethylamine; In dichloromethane; for 72h;

Reference yield:

phosgene (75-44-5) + i-Amyl alcohol (123-51-3) → carbonochloridic acid 3-methyl-butyl ester (628-50-2)

Guidance literature:

upstream raw materials:

phosgene

i-Amyl alcohol

bis(trichloromethyl) carbonate

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-1-(hydroxymethyl)-3,4-dihydroquinolin-2-(1H )-one

Downstream raw materials:

diisoamyl carbonate

(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl isopentyl carbonate

4-t-amylphenol

Refernces

• 1、 Jhansi Rani,Raghavendra,Kishore,Nanda Kumar,Hema Kumar,Jagadeeswarareddy. "Synthesis and biological activity evaluation of cytidine-5′-deoxy-5- fluoro-N-[(alkoxy/aryloxy)] carbonyl-cyclic 2′,3′-carbonates". experimental part. p. 690 - 696. Retrieved 2012/09/08.
• 2、 Forbes, Judith E.,Saicic, Radomir N.,Zard, Samir Z.. "New radical reactions of S-alkoxycarbonyl xanthates. Total synthesis of (±)-cinnamolide and (±)-methylenolactocin". . p. 3791 - 3802. Retrieved 2007/10/03.