1-(4-Aminophenyl)ethanol

Base Information

• Chemical Name: 1-(4-Aminophenyl)ethanol
• CAS No.: 14572-89-5
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.181
• Hs Code.: 2922199090
• European Community (EC) Number: 238-613-2
• DSSTox Substance ID: DTXSID70932682
• Nikkaji Number: J141.593J
• Mol file: 14572-89-5.mol

Synonyms:1-(4-Aminophenyl)ethanol;14572-89-5;4-aminophenyl ethanol;4-(1-Hydroxyethyl)aniline;1-(4-aminophenyl)ethan-1-ol;4-Amino-alpha-methylbenzyl alcohol;EINECS 238-613-2;1-(p-aminophenyl)ethanol;1-(4-aminophenyl)-ethanol;SCHEMBL56667;1-(4-amino-phenyl)-ethanol;alpha-(p-aminophenyl)-ethanol;4-Amino-a-methyl-benzenemethanol;4-amino-alpha-methylbenzylalcohol;DTXSID70932682;4-(1-Hydroxyethyl)aniline, 97%;MFCD00014781;STK340144;AKOS004114715;AKOS016050381;Benzenemethanol, 4-amino-alpha-methyl-;VS-0359;BB 0257514;CS-0044939;FT-0605649;4-SULFAMOYLPHENYLBORONICACID,PINACOLESTER;EN300-233934;N10377;A808402;J-008141

Chemical Property of 1-(4-Aminophenyl)ethanol

Chemical Property:

• Appearance/Colour: powder
• Vapor Pressure: 0.00108mmHg at 25°C
• Melting Point: 70-74 °C(lit.)
• Refractive Index: 1.592
• Boiling Point: 288.5 °C at 760 mmHg
• PKA: 14.89±0.20(Predicted)
• Flash Point: 128.3 °C
• PSA: 46.25000
• Density: 1.117 g/cm³
• LogP: 1.90330
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 97.4

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Aminophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=C(C=C1)N)O

Technology Process of 1-(4-Aminophenyl)ethanol

There total 27 articles about 1-(4-Aminophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(4-nitrophenyl)ethanone (100-19-6) → 1-(4-aminophenyl)ethanol (93453-80-6,14572-89-5)

Guidance literature:

With sodium tetrahydroborate; In water; at 25 ℃; for 2h; Sealed tube;

DOI:10.1007/s10562-021-03688-4

Reference yield: 96.5%

p-aminobenzophenone (99-92-3) → 1-(4-aminophenyl)ethanol (93453-80-6,14572-89-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 5h;

DOI:10.1016/j.tetlet.2006.05.157

Reference yield: 89.0%

4-azidoacetophenone (20062-24-2) → 1-(4-aminophenyl)ethanol (93453-80-6,14572-89-5) + p-aminobenzophenone (99-92-3) + 4-aminoethylbenzene (589-16-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 25 ℃; for 1.5h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2016.08.002

upstream raw materials:

p-aminobenzophenone

4-ethylnitrobenzene

(4-nitrophenyl)ethanone

α-(2,4-dinitrophenyl)ethyl nitrate

Downstream raw materials:

4-[1-(5-methylfuran-2-yl)ethyl]phenylamine

4-vinyl benzylamine

4-aminoethylbenzene

2,3-bis-(4-amino-phenyl)-butane-2,3-diol