6,8-dibromo-1,4-dihydro-2H-3,1-benzoxazin-2-one

Base Information

• Chemical Name: 6,8-dibromo-1,4-dihydro-2H-3,1-benzoxazin-2-one
• CAS No.: 76928-37-5
• Molecular Formula: C₈H₅Br₂NO₂
• Molecular Weight: 306.941
• Mol file: 76928-37-5.mol

Synonyms:6,8-dibromo-1,4-dihydro-2H-3,1-benzoxazin-2-one

Chemical Property of 6,8-dibromo-1,4-dihydro-2H-3,1-benzoxazin-2-one

Chemical Property:

• Vapor Pressure: 0.00093mmHg at 25°C
• Boiling Point: 303.4°C at 760 mmHg
• Flash Point: 137.3°C
• PSA: 41.82000
• Density: 2.016g/cm³
• LogP: 2.72290

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,8-dibromo-1,4-dihydro-2H-3,1-benzoxazin-2-one

There total 2 articles about 6,8-dibromo-1,4-dihydro-2H-3,1-benzoxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

carbon tetrabromide (558-13-4) + (2-amino-3,5-dibromophenyl)methanol (50739-76-9) → 6,8-dibromo-1H-benzo[d][1,3]oxazin-2(4H)-one (76928-37-5)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; potassium carbonate; In acetonitrile; for 6h; Irradiation;

DOI:10.1021/acs.orglett.6b02811

Reference yield:

2-amino-3,5-dibromo-benzoic acid methyl ester (606-00-8) → 6,8-dibromo-1H-benzo[d][1,3]oxazin-2(4H)-one (76928-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

2: tris(2,2'-bipyridyl)ruthenium dichloride; potassium carbonate / acetonitrile / 6 h / Irradiation

With lithium aluminium tetrahydride; tris(2,2'-bipyridyl)ruthenium dichloride; potassium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1021/acs.orglett.6b02811

upstream raw materials:

carbon tetrabromide

(2-amino-3,5-dibromophenyl)methanol

2-amino-3,5-dibromo-benzoic acid methyl ester

Refernces