50739-76-9Relevant articles and documents
Efficient production method of bromhexine hydrochloride
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Paragraph 0081-0087; 0099-0102; 0110-0113; 0121-0123, (2021/01/28)
The invention belongs to the technical field of biological medicines, and particularly relates to an efficient production method of bromhexine hydrochloride. The production method of bromhexine hydrochloride comprises the following steps: (1) reducing 3,5-dibromo-2-aminobenzaldehyde by a reducing agent to obtain an intermediate 3,5-dibromo-2-aminobenzyl alcohol; (2) reacting the intermediate 3,5-dibromo-2-aminobenzyl alcohol with N-methylcyclohexylamine, and then carrying out salt forming reaction to obtain a bromhexine hydrochloride crude product; and (3) purifying the bromhexine hydrochloride crude product to obtain the bromhexine hydrochloride.
A preparation method of bromhexine hydrochloride (by machine translation)
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, (2019/04/10)
The invention belongs to the field of organic synthesis, provides a bromhexine hydrochloride of the preparation method. The invention relates to 2 - aminobenzoic acid ester compound as a raw material, by the bromo reaction, reduction reaction, condensatio
A preparation method of bromhexine hydrochloride
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Paragraph 0028; 0029; 0030, (2017/05/20)
The invention provides a preparation method of bromhexine hydrochloride. 2-amino-3,5-dibromo benzaldehyde is taken as a raw material, and reduction, amination and salifying are carried out, so that the bromhexine hydrochloride is obtained, wherein amination and salifying are completed in one step, and an intermediate product is not needed to be separated. The preparation method of the bromhexine hydrochloride has the advantages that reaction steps are reduced, and yield and purity of the bromhexine hydrochloride product are improved.