1-(4-(2-Hydroxy-5-methoxyphenyl)-1-oxo-4-phenylbutyl)-1-piperazineethanol

Base Information

Chemical Name:1-(4-(2-Hydroxy-5-methoxyphenyl)-1-oxo-4-phenylbutyl)-1-piperazineethanol
CAS No.:104688-47-3
Molecular Formula:C23H30 N2 O4
Molecular Weight:398.502
Hs Code.:
DSSTox Substance ID:DTXSID10909131
Nikkaji Number:J293.239C

Synonyms:BRN 4211482;1-(4-(2-Hydroxy-5-methoxyphenyl)-1-oxo-4-phenylbutyl)-1-piperazineethanol;1-Piperazineethanol, 1-(4-(2-hydroxy-5-methoxyphenyl)-1-oxo-4-phenylbutyl)-;104688-47-3;DTXSID10909131;1-[4-(2-hydroxyethyl)piperazin-1-yl]-4-(2-hydroxy-5-methoxyphenyl)-4-phenylbutan-1-one

Suppliers and Price of 1-(4-(2-Hydroxy-5-methoxyphenyl)-1-oxo-4-phenylbutyl)-1-piperazineethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-(4-(2-Hydroxy-5-methoxyphenyl)-1-oxo-4-phenylbutyl)-1-piperazineethanol

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:398.22055744
Heavy Atom Count:29
Complexity:489

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)O)C(CCC(=O)N2CCN(CC2)CCO)C3=CC=CC=C3

Technology Process of 1-(4-(2-Hydroxy-5-methoxyphenyl)-1-oxo-4-phenylbutyl)-1-piperazineethanol

There total 3 articles about 1-(4-(2-Hydroxy-5-methoxyphenyl)-1-oxo-4-phenylbutyl)-1-piperazineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 104688-83-7
7-Methoxy-5-phenyl-2,3,4,5-tetrahydro-1-benzoxazepin-2-one

: 104688-47-3
1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-4-(2-hydroxy-5-methoxy-phenyl)-4-phenyl-butan-1-one

Guidance literature:: With triethylamine; In toluene; Ambient temperature;
DOI:10.1248/cpb.38.1570

Reference yield:

: 1008-76-0
4,5-dihydro-5-phenyl-2(3H)-furanone

: 104688-47-3
1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-4-(2-hydroxy-5-methoxy-phenyl)-4-phenyl-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / 75percent PPA / 5 h / Ambient temperature

2: 78 percent / triethylamine / toluene / Ambient temperature

With triethylamine; In toluene;
DOI:10.1248/cpb.38.1570

Reference yield:

: 150-76-5
4-methoxy-phenol

: 104688-47-3
1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-4-(2-hydroxy-5-methoxy-phenyl)-4-phenyl-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / 75percent PPA / 5 h / Ambient temperature

2: 78 percent / triethylamine / toluene / Ambient temperature

With triethylamine; In toluene;
DOI:10.1248/cpb.38.1570