3H-Benz[e]indole-3-carboxylic acid, 1-(chloromethyl)-1,2-dihydro-7-[[4-[[2-[[[2-[[(2-methoxy-2-oxoethyl)amino ]carbonyl]-1-methyl-1H-imidazol-4-yl]amino]carbonyl]-1-methyl-1H-imid azol-4-yl]amino]-1,4-dioxobutyl]amino]-5-(phenylmethoxy)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:3H-Benz[e]indole-3-carboxylic acid, 1-(chloromethyl)-1,2-dihydro-7-[[4-[[2-[[[2-[[(2-methoxy-2-oxoethyl)amino ]carbonyl]-1-methyl-1H-imidazol-4-yl]amino]carbonyl]-1-methyl-1H-imid azol-4-yl]amino]-1,4-dioxobutyl]amino]-5-(phenylmethoxy)-, 1,1-dimethylethyl ester
CAS No.:633302-93-9
Molecular Formula:C42H46ClN9O9
Molecular Weight:856.335
Hs Code.:

3H-Benz[e]indole-3-carboxylic acid,
1-(chloromethyl)-1,2-dihydro-7-[[4-[[2-[[[2-[[(2-methoxy-2-oxoethyl)amino
]carbonyl]-1-methyl-1H-imidazol-4-yl]amino]carbonyl]-1-methyl-1H-imid
azol-4-yl]amino]-1,4-dioxobutyl]amino]-5-(phenylmethoxy)-,
1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of 3H-Benz[e]indole-3-carboxylic acid, 1-(chloromethyl)-1,2-dihydro-7-[[4-[[2-[[[2-[[(2-methoxy-2-oxoethyl)amino ]carbonyl]-1-methyl-1H-imidazol-4-yl]amino]carbonyl]-1-methyl-1H-imid azol-4-yl]amino]-1,4-dioxobutyl]amino]-5-(phenylmethoxy)-, 1,1-dimethylethyl ester

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Chemical Property of 3H-Benz[e]indole-3-carboxylic acid, 1-(chloromethyl)-1,2-dihydro-7-[[4-[[2-[[[2-[[(2-methoxy-2-oxoethyl)amino ]carbonyl]-1-methyl-1H-imidazol-4-yl]amino]carbonyl]-1-methyl-1H-imid azol-4-yl]amino]-1,4-dioxobutyl]amino]-5-(phenylmethoxy)-, 1,1-dimethylethyl ester

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Technology Process of 3H-Benz[e]indole-3-carboxylic acid, 1-(chloromethyl)-1,2-dihydro-7-[[4-[[2-[[[2-[[(2-methoxy-2-oxoethyl)amino ]carbonyl]-1-methyl-1H-imidazol-4-yl]amino]carbonyl]-1-methyl-1H-imid azol-4-yl]amino]-1,4-dioxobutyl]amino]-5-(phenylmethoxy)-, 1,1-dimethylethyl ester

There total 5 articles about 3H-Benz[e]indole-3-carboxylic acid, 1-(chloromethyl)-1,2-dihydro-7-[[4-[[2-[[[2-[[(2-methoxy-2-oxoethyl)amino ]carbonyl]-1-methyl-1H-imidazol-4-yl]amino]carbonyl]-1-methyl-1H-imid azol-4-yl]amino]-1,4-dioxobutyl]amino]-5-(phenylmethoxy)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120095-64-9
2,2,2-trichloro-1-(1-methyl-4-nitro-1H-imidazol-2-yl)ethan-1-one

: 633302-93-9
5-benzyloxy-1-chloromethyl-7-(3-{2-[2-(methoxycarbonylmethylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}propionylamino)-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / Et₃N / tetrahydrofuran / 4 h / 20 °C

2: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

3: 1.3 g / Et₃N / tetrahydrofuran / 2 h / 20 °C

4: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

5: 1.0 g / HOBt; EDCI / dimethylformamide / 12 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1039/b303650m

Reference yield:

: 633302-89-3
[(1-methyl-4-nitro-1H-imidazole-2-carbonyl)amino]acetic acid methyl ester

: 633302-93-9
5-benzyloxy-1-chloromethyl-7-(3-{2-[2-(methoxycarbonylmethylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}propionylamino)-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

2: 1.3 g / Et₃N / tetrahydrofuran / 2 h / 20 °C

3: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

4: 1.0 g / HOBt; EDCI / dimethylformamide / 12 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1039/b303650m

Reference yield:

: 633302-90-6
({1-methyl-4-[(1-methyl-4-nitro-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)acetic acid methyl ester

: 633302-93-9
5-benzyloxy-1-chloromethyl-7-(3-{2-[2-(methoxycarbonylmethylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}propionylamino)-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

2: 1.0 g / HOBt; EDCI / dimethylformamide / 12 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/b303650m