3H-Benz[e]indole-3-carboxylic acid, 7-[(3-carboxy-1-oxopropyl)amino]-1-(chloromethyl)-1,2-dihydro-5-(phen ylmethoxy)-, 3-(1,1-dimethylethyl) ester

Base Information

Chemical Name:3H-Benz[e]indole-3-carboxylic acid, 7-[(3-carboxy-1-oxopropyl)amino]-1-(chloromethyl)-1,2-dihydro-5-(phen ylmethoxy)-, 3-(1,1-dimethylethyl) ester
CAS No.:439599-60-7
Molecular Formula:C29H31ClN2O6
Molecular Weight:539.028
Hs Code.:

3H-Benz[e]indole-3-carboxylic acid,
7-[(3-carboxy-1-oxopropyl)amino]-1-(chloromethyl)-1,2-dihydro-5-(phen
ylmethoxy)-, 3-(1,1-dimethylethyl) ester

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Chemical Property of 3H-Benz[e]indole-3-carboxylic acid, 7-[(3-carboxy-1-oxopropyl)amino]-1-(chloromethyl)-1,2-dihydro-5-(phen ylmethoxy)-, 3-(1,1-dimethylethyl) ester

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Technology Process of 3H-Benz[e]indole-3-carboxylic acid, 7-[(3-carboxy-1-oxopropyl)amino]-1-(chloromethyl)-1,2-dihydro-5-(phen ylmethoxy)-, 3-(1,1-dimethylethyl) ester

There total 1 articles about 3H-Benz[e]indole-3-carboxylic acid, 7-[(3-carboxy-1-oxopropyl)amino]-1-(chloromethyl)-1,2-dihydro-5-(phen ylmethoxy)-, 3-(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-30-5
succinic acid anhydride

: 286374-31-0
7-amino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

: 439599-60-7
5-benzyloxy-7-(3-carboxypropionylamino)-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1039/b303650m

Reference yield: 80.0%

: 162085-96-3
H-Py-Py-Py-OMe hydrochloride

: 439599-60-7
5-benzyloxy-7-(3-carboxypropionylamino)-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

: 439599-62-9
5-benzyloxy-1-chloromethyl-7-(3-{5-[5-(5-methoxycarbonyl-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}propionylamino)-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/ol020047k

Reference yield:

: 126092-99-7
methyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate

: 439599-60-7
5-benzyloxy-7-(3-carboxypropionylamino)-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

: 633302-61-1
5-benzyloxy-1-chloromethyl-7-{3-[5-(5-methoxycarbonyl-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]propionylamino}-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1039/b303650m