3H-Benz[e]indole-3-carboxylic acid, 7-amino-1-(chloromethyl)-1,2-dihydro-5-(phenylmethoxy)-, 1,1-dimethylethyl ester

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Chemical Name:3H-Benz[e]indole-3-carboxylic acid, 7-amino-1-(chloromethyl)-1,2-dihydro-5-(phenylmethoxy)-, 1,1-dimethylethyl ester
CAS No.:286374-31-0
Molecular Formula:C25H27ClN2O3
Molecular Weight:438.954
Hs Code.:
Mol file:286374-31-0.mol

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Chemical Property of 3H-Benz[e]indole-3-carboxylic acid, 7-amino-1-(chloromethyl)-1,2-dihydro-5-(phenylmethoxy)-, 1,1-dimethylethyl ester Edit

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Technology Process of 3H-Benz[e]indole-3-carboxylic acid, 7-amino-1-(chloromethyl)-1,2-dihydro-5-(phenylmethoxy)-, 1,1-dimethylethyl ester

There total 2 articles about 3H-Benz[e]indole-3-carboxylic acid, 7-amino-1-(chloromethyl)-1,2-dihydro-5-(phenylmethoxy)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 222835-56-5
5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole

: 286374-31-0
7-amino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 1h;
DOI:10.1016/S0968-0896(00)00088-2

Reference yield:

: 222835-55-4
N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

: 286374-31-0
7-amino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / n-Bu₃SnH; AIBN / benzene / 4 h / Heating

2: 96 percent / TBAF / tetrahydrofuran / 1 h / 23 °C

With 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; In tetrahydrofuran; benzene; 1: Cyclization / 2: Substitution;
DOI:10.1016/S0968-0896(00)00088-2