1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester
CAS No.:633698-88-1
Molecular Formula:C27H34F2N4O6S
Molecular Weight:580.653
Hs Code.:

1H-Imidazole-1-carboxylic acid,
2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl
amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester

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Technology Process of 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester

There total 10 articles about 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methyl amino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 633698-75-6
4,5-dihydro-2-[4-[[methyl[[2-(methylamino)ethoxy]acetyl]amino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

: 60230-36-6
2,6-difluorobenzene-1-sulfonyl chloride

: 633698-88-1
2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm2016057

Reference yield: 49.0%

: 633698-88-1
2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:

Reference yield:

: 441295-89-2
[(4-cyanophenyl)methyl]methylcarbamic acid phenylmethyl ester

: 633698-88-1
2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sulfur / 2 h / 100 °C

2: dmap / dichloromethane / 2 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

6: triethylamine / dichloromethane / 2 h / 20 °C

With dmap; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm2016057