1,1'-Biisoquinoline, 1,1',2,2',3,3',4,4'-octahydro-, (1R,1'R)-

Base Information

Chemical Name:1,1'-Biisoquinoline, 1,1',2,2',3,3',4,4'-octahydro-, (1R,1'R)-
CAS No.:634180-49-7
Molecular Formula:C18H20N2
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID70460596
Nikkaji Number:J1.721.111K
Wikidata:Q82284699

Synonyms:634180-49-7;(1R,1'R)-1,1',2,2',3,3',4,4'-Octahydro-1,1'-biisoquinoline;1,1'-Biisoquinoline, 1,1',2,2',3,3',4,4'-octahydro-, (1R,1'R)-;SCHEMBL24017043;DTXSID70460596;BS-52027;CS-0134913;E84950;(1R)-1-[(1R)-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL]-1,2,3,4-TETRAHYDROISOQUINOLINE

Suppliers and Price of 1,1'-Biisoquinoline, 1,1',2,2',3,3',4,4'-octahydro-, (1R,1'R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1,1'-Biisoquinoline, 1,1',2,2',3,3',4,4'-octahydro-, (1R,1'R)-

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:264.162648646
Heavy Atom Count:20
Complexity:297

Purity/Quality:: 97%HPLC;99 %ee ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNC(C2=CC=CC=C21)C3C4=CC=CC=C4CCN3
Isomeric SMILES:C1CN[C@H](C2=CC=CC=C21)[C@H]3C4=CC=CC=C4CCN3

Technology Process of 1,1'-Biisoquinoline, 1,1',2,2',3,3',4,4'-octahydro-, (1R,1'R)-

There total 4 articles about 1,1'-Biisoquinoline, 1,1',2,2',3,3',4,4'-octahydro-, (1R,1'R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3230-65-7
3,4-dihydroisoquinoline

: 634180-49-7,634180-45-3
(1R,1'R)-1,1',2,2',3,3',4,4'-octahydro-1,1'-biisoquinoline

Guidance literature:: 3,4-dihydroisoquinoline; With (5R,5'R)-4,4,4',4'-tetrakis(2,5-dimethylphenyl)-5,5'-diphenyl-2,2'-bi(1,3,2-dioxaborolane); In tetrahydrofuran; at 20 ℃; for 12h;

With hydrogenchloride; In tetrahydrofuran; enantioselective reaction;
DOI:10.1021/jacs.0c04558

Reference yield: 31.0%

: 634180-45-3
(1RS,1'RS)-1,1',2,2',3,3',4,4'-octahydro-1,1'-biisoquinoline

: 634180-49-7,634180-45-3
(1R,1'R)-1,1',2,2',3,3',4,4'-octahydro-1,1'-biisoquinoline

: 634180-45-3
(+)-(1S,1'S)-1,2,3,4,1',2',3',4'-octahydro-1,1'-bisisoquinoline

Guidance literature:: (1RS,1'RS)-1,1',2,2',3,3',4,4'-octahydro-1,1'-biisoquinoline; With (R)-10-camphorsulfonic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium hydroxide; In methanol; ethanol;
DOI:10.1002/ejoc.200500301

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 634180-49-7,634180-45-3
(1R,1'R)-1,1',2,2',3,3',4,4'-octahydro-1,1'-biisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: N-chloro-succinimide / diethyl ether / 2 h / 20 °C

2: potassium hydroxide / diethyl ether; ethanol / 3 h / 20 °C

3: (5R,5'R)-4,4,4',4'-tetrakis(2,5-dimethylphenyl)-5,5'-diphenyl-2,2'-bi(1,3,2-dioxaborolane) / tetrahydrofuran / 12 h / 20 °C

With N-chloro-succinimide; (5R,5'R)-4,4,4',4'-tetrakis(2,5-dimethylphenyl)-5,5'-diphenyl-2,2'-bi(1,3,2-dioxaborolane); potassium hydroxide; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1021/jacs.0c04558