Benzoic acid, 4,5-dichloro-2-hydroxy-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 4,5-dichloro-2-hydroxy-, methyl ester
• CAS No.: 63483-07-8
• Molecular Formula: C8H6Cl2O3
• Molecular Weight: 221.04
• Mol file: 63483-07-8.mol

Synonyms:4,5-Dichloro-2-hydroxy-benzoic acid methyl ester;4,5-Dichlorsalicylsaeuremethylester;

Chemical Property of Benzoic acid, 4,5-dichloro-2-hydroxy-, methyl ester

Chemical Property:

• Melting Point: 100 - 101 °C
• PSA: 46.53000
• LogP: 2.48560

Purity/Quality:

98% ^*data from raw suppliers

Methyl4,5-dichloro-2-hydroxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4,5-dichloro-2-hydroxy-, methyl ester

There total 1 articles about Benzoic acid, 4,5-dichloro-2-hydroxy-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 4,5-dichloro-2-hydroxybenzoic acid (50274-58-3) → methyl 4,5-dichloro-2-hydroxybenzoate (63483-07-8)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.1016/j.bmc.2017.01.016

Reference yield: 97.0%

methyl 4,5-dichloro-2-hydroxybenzoate (63483-07-8) → 4,5-dichloro-2-hydroxybenzoic acid (50274-58-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;

DOI:10.1016/j.bmc.2017.01.016

Reference yield:

methyl 4,5-dichloro-2-hydroxybenzoate (63483-07-8) → 6,7-dichloro-2-(2-chloro-ethyl)-3-hydroxy-2,3-dihydro-benzo[e][1,3]oxazin-4-one (63482-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH

2: HCl / acetic acid

With hydrogenchloride; hydroxylamine; In acetic acid;

upstream raw materials:

methanol

4,5-dichloro-2-hydroxybenzoic acid

Downstream raw materials:

4,5-dichloro-2-hydroxy-benzoic acid amide

4,5-dichloro-2,N-dihydroxy-benzamide

2-butoxy-4,5-dichloro-benzoic acid amide

6,7-dichloro-2-(2-chloro-ethyl)-3-hydroxy-2,3-dihydro-benzo[e][1,3]oxazin-4-one