3-Methylisoquinolin-7-ol

Base Information

• Chemical Name: 3-Methylisoquinolin-7-ol
• CAS No.: 63485-73-4
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Hs Code.: 2933499090
• Mol file: 63485-73-4.mol

Synonyms:1-Methylisoquinolin-5-ol;3-Methylisoquinolin-7-ol;3-Methyl-7-hydroxyisoquinoline;

Chemical Property of 3-Methylisoquinolin-7-ol

Chemical Property:

• Melting Point: 252-255℃
• Boiling Point: 329.7 °C at 760 mmHg
• Flash Point: 153.2 °C
• PSA: 33.12000
• Density: 1.21 g/cm³
• LogP: 2.24880
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

7-Hydroxy-3-methylisoquinoline 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methylisoquinolin-7-ol

There total 5 articles about 3-Methylisoquinolin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

7-methoxy-3-methylisoquinoline (40134-07-4) → 3-methyl-isoquinolin-7-ol (63485-73-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

3-METHOXYBENZYLAMINE (5071-96-5) → 3-methyl-isoquinolin-7-ol (63485-73-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium sulfate; acetic acid / 1.5 h / 20 °C

1.2: 2.67 h

1.3: pH 7

2.1: trifluoroacetic acid / 55 °C / Inert atmosphere

3.1: air / copper(l) iodide / isopropyl alcohol / 54 h / 20 - 55 °C

4.1: boron tribromide / dichloromethane / 2.5 h / 20 °C

With boron tribromide; acetic acid; sodium sulfate; trifluoroacetic acid; copper(l) iodide; In dichloromethane; isopropyl alcohol;

Reference yield:

1,1-dimethoxy-N-(3-methoxybenzyl)propan-2-amine (83903-87-1) → 3-methyl-isoquinolin-7-ol (63485-73-4)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / 55 °C / Inert atmosphere

2: air / copper(l) iodide / isopropyl alcohol / 54 h / 20 - 55 °C

3: boron tribromide / dichloromethane / 2.5 h / 20 °C

With boron tribromide; trifluoroacetic acid; copper(l) iodide; In dichloromethane; isopropyl alcohol;

upstream raw materials:

3-METHOXYBENZYLAMINE

1,1-dimethoxy-N-(3-methoxybenzyl)propan-2-amine

7-methoxy-3-methylisoquinoline

C₁₁H₁₃NO

Downstream raw materials:

7-(trans-4-tert-butylcyclohexyloxy)-3-methylisoquinoline

7-(trans-4-tert-butylcyclohexyloxy)isoquinoline-3-carbaldehyde

1-[7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-ylmethyl]piperidine-4-carboxylic acid ethyl ester

3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid

Refernces