3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid

Base Information

Chemical Name:3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid
CAS No.:1266118-75-5
Molecular Formula:C₂₃H₃₂N₂O₃
Molecular Weight:384.519
Hs Code.:

Synonyms:3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid

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Chemical Property of 3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid

Chemical Property:

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Technology Process of 3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid

There total 6 articles about 3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoate

: 1266118-75-5
3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid

Guidance literature:: tert-butyl 3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; for 2h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 937-05-3
cis-4-tert-butyl-1-cyclohexanol

: 1266118-75-5
3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / toluene / 0.25 h

1.2: 20 °C

2.1: selenium(IV) oxide / diphenylether / 4 h / 200 °C / Sealed tube

3.1: triethylamine / 1,2-dichloro-ethane / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2 h

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h

With selenium(IV) oxide; lithium hydroxide monohydrate; water; sodium tris(acetoxy)borohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diphenylether; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1266118-71-1
7-(trans-4-tert-butylcyclohexyloxy)-3-methylisoquinoline

: 1266118-75-5
3-(((7-(trans-4-tert-butylcyclohexyloxy)isoquinolin-3-yl)methyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: selenium(IV) oxide / diphenylether / 4 h / 200 °C / Sealed tube

2: triethylamine / 1,2-dichloro-ethane / 1 h / 20 °C

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2 h

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h

With selenium(IV) oxide; lithium hydroxide monohydrate; water; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; methanol; diphenylether; 1,2-dichloro-ethane;