(3R,4S)-1-tert-butoxycarbonyl-4-cyclohexylthiomethyl-3-hydroxypyrrolidine

Base Information

Chemical Name:(3R,4S)-1-tert-butoxycarbonyl-4-cyclohexylthiomethyl-3-hydroxypyrrolidine
CAS No.:742079-59-0
Molecular Formula:C₁₆H₂₉NO₃S
Molecular Weight:315.477
Hs Code.:

Synonyms:(3R,4S)-1-tert-butoxycarbonyl-4-cyclohexylthiomethyl-3-hydroxypyrrolidine

Suppliers and Price of (3R,4S)-1-tert-butoxycarbonyl-4-cyclohexylthiomethyl-3-hydroxypyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4S)-1-tert-butoxycarbonyl-4-cyclohexylthiomethyl-3-hydroxypyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4S)-1-tert-butoxycarbonyl-4-cyclohexylthiomethyl-3-hydroxypyrrolidine

There total 2 articles about (3R,4S)-1-tert-butoxycarbonyl-4-cyclohexylthiomethyl-3-hydroxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 666831-24-9
tert-butyl (3R,4R)-3-hydroxy-4-[(methanesulfonyloxy)methyl]pyrrolidine-1-carboxylate

: 1569-69-3
Cyclohexanethiol

: 742079-59-0
(3R,4S)-1-tert-butoxycarbonyl-4-cyclohexylthiomethyl-3-hydroxypyrrolidine

Guidance literature:: With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 0.166667h;

Reference yield:

: 635319-09-4
tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate

: 742079-59-0
(3R,4S)-1-tert-butoxycarbonyl-4-cyclohexylthiomethyl-3-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2.1 g / diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

2.1: NaH / dimethylformamide / 0.17 h / 0 °C

2.2: dimethylformamide / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050269z