5H-Pyrrolo[3,2-d]pyrimidine, 4-(1,1-dimethylethoxy)-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenyl methoxy)-4-[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-

Base Information

Chemical Name:5H-Pyrrolo[3,2-d]pyrimidine, 4-(1,1-dimethylethoxy)-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenyl methoxy)-4-[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-
CAS No.:635319-15-2
Molecular Formula:C38H44N4O4
Molecular Weight:620.792
Hs Code.:

5H-Pyrrolo[3,2-d]pyrimidine,
4-(1,1-dimethylethoxy)-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenyl
methoxy)-4-[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-

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Chemical Property of 5H-Pyrrolo[3,2-d]pyrimidine, 4-(1,1-dimethylethoxy)-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenyl methoxy)-4-[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-

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Technology Process of 5H-Pyrrolo[3,2-d]pyrimidine, 4-(1,1-dimethylethoxy)-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenyl methoxy)-4-[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]-

There total 4 articles about 5H-Pyrrolo[3,2-d]pyrimidine, 4-(1,1-dimethylethoxy)-5-[(phenylmethoxy)methyl]-7-[[(3R,4R)-3-(phenyl methoxy)-4-[(phenylmethoxy)methyl]-1-pyrrolidinyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 635319-12-9
7-benzyloxymethyl-6-O-tert-butyl-9-deaza-9-formylhypoxanthine

: (3R,4R)-3-benzyloxy-4-benzyloxymethylpyrrolidine hydrochloride

: 635319-15-2
7-(3-benzyloxy-4-benzyloxymethyl-pyrrolidin-1-ylmethyl)-5-benzyloxymethyl-4-tert-butoxy-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃;
DOI:10.1021/jm030305z

Reference yield:

: 299916-78-2
7-N-benzyloxymethyl-9-bromo-6-O-tert-butyl-9-deaza-hypoxanthine

: 635319-15-2
7-(3-benzyloxy-4-benzyloxymethyl-pyrrolidin-1-ylmethyl)-5-benzyloxymethyl-4-tert-butoxy-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; methoxybenzene / 0.5 h / -78 °C

1.2: 78 percent / diethyl ether; methoxybenzene / 0.5 h / -78 °C

2.1: NaCNBH₃ / methanol / 20 °C

With n-butyllithium; sodium cyanoborohydride; In methanol; diethyl ether; methoxybenzene;
DOI:10.1021/jm030305z

Reference yield:

: 635319-09-4
tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate

: 635319-15-2
7-(3-benzyloxy-4-benzyloxymethyl-pyrrolidin-1-ylmethyl)-5-benzyloxymethyl-4-tert-butoxy-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / NaH / dimethylformamide / 0 - 20 °C

2: 100 percent / aq. HCl / methanol / 1 h / 40 °C

3: NaCNBH₃ / methanol / 20 °C

With hydrogenchloride; sodium hydride; sodium cyanoborohydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030305z