3-Pyrrolidinemethanol, 1-[[2-[bis[(4-methoxyphenyl)methyl]amino]-4-(phenylmethoxy)-5-[(phenyl methoxy)methyl]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl]-4-hydroxy-, (3R,4R)-

Base Information

Chemical Name:3-Pyrrolidinemethanol, 1-[[2-[bis[(4-methoxyphenyl)methyl]amino]-4-(phenylmethoxy)-5-[(phenyl methoxy)methyl]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl]-4-hydroxy-, (3R,4R)-
CAS No.:635319-16-3
Molecular Formula:C43H47N5O6
Molecular Weight:729.876
Hs Code.:

3-Pyrrolidinemethanol,
1-[[2-[bis[(4-methoxyphenyl)methyl]amino]-4-(phenylmethoxy)-5-[(phenyl
methoxy)methyl]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl]-4-hydroxy-,
(3R,4R)-

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Chemical Property of 3-Pyrrolidinemethanol, 1-[[2-[bis[(4-methoxyphenyl)methyl]amino]-4-(phenylmethoxy)-5-[(phenyl methoxy)methyl]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl]-4-hydroxy-, (3R,4R)-

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Technology Process of 3-Pyrrolidinemethanol, 1-[[2-[bis[(4-methoxyphenyl)methyl]amino]-4-(phenylmethoxy)-5-[(phenyl methoxy)methyl]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl]-4-hydroxy-, (3R,4R)-

There total 3 articles about 3-Pyrrolidinemethanol, 1-[[2-[bis[(4-methoxyphenyl)methyl]amino]-4-(phenylmethoxy)-5-[(phenyl methoxy)methyl]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl]-4-hydroxy-, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1609403-89-5,217449-25-7
(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine hydrochloride

: 635319-13-0
7-benzyloxymethyl-6-O-benzyl-9-deaza-9-formyl-2-N-bis(4-methoxybenzyl)guanine

: 635319-16-3
(3R,4R)-1-{[6-O-benzyl-7-benzyloxymethyl-9-deaza-2-bis(4-methoxybenzyl)guanin-9-yl]methyl}-3-hydroxy-4-hydroxymethylpyrrolidine

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃;
DOI:10.1021/jm030305z

Reference yield:

: 635319-09-4
tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate

: 635319-16-3
(3R,4R)-1-{[6-O-benzyl-7-benzyloxymethyl-9-deaza-2-bis(4-methoxybenzyl)guanin-9-yl]methyl}-3-hydroxy-4-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / aq. HCl / methanol / 1 h / 20 °C

2: 70 percent / NaCNBH₃ / methanol / 20 °C

With hydrogenchloride; sodium cyanoborohydride; In methanol;
DOI:10.1021/jm030305z

Reference yield:

: 299917-02-5
6-O-benzyl-7-N-benzyloxymethyl-9-bromo-9-deaza-2-N,N-bis(4-methoxybenzyl)guanine

: 635319-16-3
(3R,4R)-1-{[6-O-benzyl-7-benzyloxymethyl-9-deaza-2-bis(4-methoxybenzyl)guanin-9-yl]methyl}-3-hydroxy-4-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; methoxybenzene / 0.5 h / -80 °C

1.2: 72 percent / diethyl ether; methoxybenzene / -80 - 20 °C

2.1: 70 percent / NaCNBH₃ / methanol / 20 °C

With n-butyllithium; sodium cyanoborohydride; In methanol; diethyl ether; methoxybenzene;
DOI:10.1021/jm030305z