4-Thiazolidinone, 2-(phenylimino)-3-propyl-

Base Information

• Chemical Name: 4-Thiazolidinone, 2-(phenylimino)-3-propyl-
• CAS No.: 63543-89-5
• Molecular Formula: C12H14N2OS
• Molecular Weight: 234.322
• Mol file: 63543-89-5.mol

Synonyms:2-phenylimino-3-propyl-thiazolidin-4-one;2-phenylimino-3-propyl-4-thiazolidinone;HMS1691L17;2-Phenylimino-3-propylthiazolidin-4-on;

Chemical Property of 4-Thiazolidinone, 2-(phenylimino)-3-propyl-

Chemical Property:

• PSA: 57.97000
• LogP: 2.59740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Thiazolidinone, 2-(phenylimino)-3-propyl-

There total 5 articles about 4-Thiazolidinone, 2-(phenylimino)-3-propyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-n-propyl-N'-phenylthiourea (13140-47-1) + chloroacetic acid (79-11-8) → 3-propyl-2-(phenylimino)-1,3-thiazolidin-4-one (63543-89-5)

Guidance literature:

With sodium acetate; In ethanol; Reflux;

DOI:10.1016/j.bmcl.2020.127549

Reference yield: 62.0%

N-n-propyl-N'-phenylthiourea (13140-47-1) + chloroacetyl chloride (79-04-9) → 3-phenyl-2-propylimino-4-thiazolidinone (859539-98-3) + 3-propyl-2-(phenylimino)-1,3-thiazolidin-4-one (63543-89-5)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃;

DOI:10.1016/j.bmc.2005.04.058

Reference yield:

phenyl isothiocyanate (103-72-0) → 3-propyl-2-(phenylimino)-1,3-thiazolidin-4-one (63543-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / CHCl₃ / 4 h / 20 °C

2: 31 percent / triethylamine / CHCl₃ / 20 °C

With triethylamine; In chloroform;

DOI:10.1016/j.bmc.2005.04.058

upstream raw materials:

N-n-propyl-N'-phenylthiourea

chloroacetic acid ethyl ester

chloroacetyl chloride

phenyl isothiocyanate