2-tert-Butyl-3-hydroxypyridine

Base Information

• Chemical Name: 2-tert-Butyl-3-hydroxypyridine
• CAS No.: 63688-34-6
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.208
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10213083
• Wikidata: Q83088353
• Mol file: 63688-34-6.mol

Synonyms:2-tert-butyl-3-hydroxypyridine;2-tert-butyl-3-hydroxypyridine hydrochloride

Chemical Property of 2-tert-Butyl-3-hydroxypyridine

Chemical Property:

• Vapor Pressure: 0.00171mmHg at 25°C
• Boiling Point: 284.7°C at 760 mmHg
• PKA: 10.52±0.10(Predicted)
• Flash Point: 126°C
• PSA: 33.12000
• Density: 1.023g/cm³
• LogP: 2.08470
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 128

Purity/Quality:

95+% ^*data from raw suppliers

2-tert-butylpyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=C(C=CC=N1)O

Technology Process of 2-tert-Butyl-3-hydroxypyridine

There total 4 articles about 2-tert-Butyl-3-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(furan-2-yl)-2,2-dimethylpropan-1-one (4208-54-2) → 2-tert-butyl-pyridin-3-ol (63688-34-6)

Guidance literature:

With ethanol; ammonia; at 170 ℃;

DOI:10.1139/v53-079

Reference yield:

2,2-dimethylpropanoic anhydride (1538-75-6) → 2-tert-butyl-pyridin-3-ol (63688-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: boron fluoride ether adduct

2: ethanol; ammonia / 170 °C

With ethanol; boron fluoride ether; ammonia;

DOI:10.1139/v53-079

Reference yield:

1-(furan-2-yl)-2,2-dimethylpropan-1-one (4208-54-2) + ethanol (64-17-5) + ammonia (7664-41-7) → 2-tert-butyl-pyridin-3-ol (63688-34-6)

Guidance literature:

at 170 ℃;

DOI:10.1139/v53-079

upstream raw materials:

1-(furan-2-yl)-2,2-dimethylpropan-1-one

ethanol

ammonia

2,2-dimethylpropanoic anhydride