2,4-Dichloro-5-phenylpyriMidine

Base Information

• Chemical Name: 2,4-Dichloro-5-phenylpyriMidine
• CAS No.: 63558-77-0
• Molecular Formula: C10H6Cl2N2
• Molecular Weight: 225.077
• Hs Code.: 2933599090
• Mol file: 63558-77-0.mol

Synonyms:2,4-Dichlor-5-phenyl-pyrimidin;2,4-dichloro-5-nitro-toluene;Phenyl-dichlorpyrimidin;2,4-dichloro-5-phenyl-pyrimidine;2,4-Dichlor-5-nitro-toluol;2,4-Dichlor-5-methyl-nitrobenzol;

Chemical Property of 2,4-Dichloro-5-phenylpyriMidine

Chemical Property:

• Melting Point: 78-80 °C
• Boiling Point: 181-182 °C(Press: 16 Torr)
• PKA: -3.13±0.29(Predicted)
• PSA: 25.78000
• Density: 1.363±0.06 g/cm3(Predicted)
• LogP: 3.45040

Purity/Quality:

≥95% ^*data from raw suppliers

2,4-dichloro-5-phenylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dichloro-5-phenylpyriMidine

There total 3 articles about 2,4-Dichloro-5-phenylpyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-phenyluracil (15761-83-8) → 2,4-dichloro-5-phenylpyrimidine (63558-77-0)

Guidance literature:

With triethylamine hydrochloride; trichlorophosphate; at 120 ℃; for 72h; Heating / reflux;

Reference yield: 60.0%

2,4-dichloro-5-bromopyrimidine (36082-50-5) + phenylboronic acid (98-80-6) → 2-chloro-5-bromo-4-phenylpyrimidine (870722-92-2) + 2,4-dichloro-5-phenylpyrimidine (63558-77-0)

Guidance literature:

With [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride; potassium carbonate; In N,N-dimethyl-formamide; toluene; at 185 ℃; for 0.166667h; Irradiation;

DOI:10.1016/j.tetlet.2006.04.082

Reference yield:

→ 2,4-dichloro-5-phenylpyrimidine (63558-77-0)

Guidance literature:

C6H5-CCl2, CH3CN;

upstream raw materials:

5-phenyluracil

2,4-dichloro-5-bromopyrimidine

phenylboronic acid

Downstream raw materials:

(2-chloro-5-phenyl-pyrimidin-4-yl)-(5-cyclopropyl-2H-pyrazol-3-yl)-amine

2-chloro-4,5-diphenylpyrimidine

Refernces

• 1、 Ceide, Susana Conde,Montalban, Antonio Garrido. "Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines". . p. 4415 - 4418. Retrieved 2007/10/03.
• 2、 -. "INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS". Page 180-181. . Retrieved 2008/06/13.