4-[(2-Fluorophenoxy)methyl]piperidine

Base Information

Chemical Name:4-[(2-Fluorophenoxy)methyl]piperidine
CAS No.:63608-34-4
Molecular Formula:C12H16FNO
Molecular Weight:209.264
Hs Code.:
DSSTox Substance ID:DTXSID201285916

Synonyms:4-[(2-fluorophenoxy)methyl]piperidine;63608-34-4;SCHEMBL1475216;GTYCVCKSMFWBQA-UHFFFAOYSA-N;DTXSID201285916;4-(2-fluorophenoxymethyl)piperidine;STL068231;AKOS000168395;MCULE-9090172542

Suppliers and Price of 4-[(2-Fluorophenoxy)methyl]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-[(2-Fluorophenoxy)methyl]piperidine

Chemical Property:

Boiling Point:305.1±12.0 °C(Predicted)
PKA:10.33±0.10(Predicted)
PSA：21.26000
Density:1.066±0.06 g/cm3(Predicted)
LogP:2.53290
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:209.121592296
Heavy Atom Count:15
Complexity:183

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1COC2=CC=CC=C2F

Technology Process of 4-[(2-Fluorophenoxy)methyl]piperidine

There total 4 articles about 4-[(2-Fluorophenoxy)methyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: tert-butyl 4-((2-fluorophenoxy)methyl)piperidine-1-carboxylate

: 63608-34-4
4-((2-fluorophenoxy)methyl)piperidine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 2h; Inert atmosphere;

Reference yield:

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 63608-34-4
4-((2-fluorophenoxy)methyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / 25 °C

1.2: 15 h / 25 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 25 °C / Inert atmosphere

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 367-12-4
2-fluorophenol

: 63608-34-4
4-((2-fluorophenoxy)methyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / 25 °C

1.2: 15 h / 25 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 25 °C / Inert atmosphere

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane;