Bromhexine

Base Information

Chemical Name:Bromhexine
CAS No.:3572-43-8
Molecular Formula:C14H20Br2N2
Molecular Weight:376.134
Hs Code.:2921590090
European Community (EC) Number:222-684-1
UNII:Q1J152VB1P
DSSTox Substance ID:DTXSID6022686
Nikkaji Number:J8.165E
Wikipedia:Bromhexine
Wikidata:Q239778
NCI Thesaurus Code:C172826
RXCUI:1753
Pharos Ligand ID:JY7YRWZRACU2
Metabolomics Workbench ID:143581
ChEMBL ID:CHEMBL253376
Mol file:3572-43-8.mol

Synonyms:Aparsonin;BC, Bromhexin;Bisolvon;Bromhexin;Bromhexin BC;Bromhexin Berlin Chemie;Bromhexin Berlin-Chemie;Bromhexin BerlinChemie;Bromhexin ratiopharm;bromhexin von ct;Bromhexin-ratiopharm;Bromhexine;Bromhexine Hydrochloride;Bromhexine Monohydrochloride;Bromhexine, Famel;Bromhexinratiopharm;Brotussol;ct, bromhexin von;Darolan;Dur Elix;Dur-Elix;DurElix;Famel Bromhexine;Flegamin;Flubron;Hustentabs ratiopharm;Hustentabs-ratiopharm;Hustentabsratiopharm;Hydrochloride, Bromhexine;Monohydrochloride, Bromhexine;Mucohexine;NA 274;NA-274;NA274;Quentan;Tesacof;von ct, bromhexin

Suppliers and Price of Bromhexine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Bromhexine 95+%
1g
$ 614.00

Chemenu
2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline 95%
1g
$ 580.00

American Custom Chemicals Corporation
N-(2-AMINO-3,5-DIBROMOBENZYL)-N-CYCLOHEXYL-N-METHYLAMINE 95.00%
50G
$ 2392.25

American Custom Chemicals Corporation
N-(2-AMINO-3,5-DIBROMOBENZYL)-N-CYCLOHEXYL-N-METHYLAMINE 95.00%
25G
$ 1422.46

American Custom Chemicals Corporation
BROMHEXINE IMPURITY E 95.00%
5MG
$ 502.80

American Custom Chemicals Corporation
N-(2-AMINO-3,5-DIBROMOBENZYL)-N-CYCLOHEXYL-N-METHYLAMINE 95.00%
1G
$ 477.38

Total 58 raw suppliers

Chemical Property of Bromhexine

Chemical Property:

Vapor Pressure:4.68E-07mmHg at 25°C
Melting Point:238℃
Refractive Index:1.626
Boiling Point:413.8 °C at 760 mmHg
PKA:8.34±0.20(Predicted)
Flash Point:204.1 °C
PSA：29.26000
Density:1.57 g/cm³
LogP:5.13950
Storage Temp.:2-8°C(protect from light)
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:375.99727
Heavy Atom Count:18
Complexity:256

Purity/Quality:

99%, ^*data from raw suppliers

Bromhexine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CC1=C(C(=CC(=C1)Br)Br)N)C2CCCCC2
Recent ClinicalTrials:Clinical Trial With N-acetylcysteine and Bromhexine for COVID-19
Uses Expectorant; mucolytic.
Therapeutic Function Expectorant; Mucolytic

Technology Process of Bromhexine

There total 4 articles about Bromhexine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 100-60-7
N-methylcyclohexylamine

: C₁₁H₉Br₂N₃O₂

: 3572-43-8
bromhexine

Guidance literature:: for 5h; Inert atmosphere; Reflux;

Reference yield:

: 50910-55-9
3,5-dibromo-2-amino benzaldehyde

: 3572-43-8
bromhexine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / -5 °C / Inert atmosphere

2: tetrahydrofuran / 1 h / 5 - 20 °C / Inert atmosphere

3: 5 h / Inert atmosphere; Reflux

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene;

Reference yield:

: 50739-76-9
(2-amino-3,5-dibromophenyl)methanol

: 3572-43-8
bromhexine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 5 - 20 °C / Inert atmosphere

2: 5 h / Inert atmosphere; Reflux

In tetrahydrofuran;