5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid,7-[[(2-amino-4-thiazolyl)- (methoxyimino)acetyl]amino]-3-[[(1-methyl- 1H-tetrazol-5-yl)thio]methyl]-8-oxo-,[6R- [6R,7â(E)]]-

Base Information

• Chemical Name: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid,7-[[(2-amino-4-thiazolyl)- (methoxyimino)acetyl]amino]-3-[[(1-methyl- 1H-tetrazol-5-yl)thio]methyl]-8-oxo-,[6R- [6R,7â(E)]]-
• CAS No.: 66340-45-2
• Molecular Formula: C16H17N9O5S3
• Mol file: 66340-45-2.mol

Synonyms:

Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid,7-[[(2-amino-4-thiazolyl)- (methoxyimino)acetyl]amino]-3-[[(1-methyl- 1H-tetrazol-5-yl)thio]methyl]-8-oxo-,[6R- [6R,7â(E)]]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid,7-[[(2-amino-4-thiazolyl)- (methoxyimino)acetyl]amino]-3-[[(1-methyl- 1H-tetrazol-5-yl)thio]methyl]-8-oxo-,[6R- [6R,7â(E)]]-

There total 4 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid,7-[[(2-amino-4-thiazolyl)- (methoxyimino)acetyl]amino]-3-[[(1-methyl- 1H-tetrazol-5-yl)thio]methyl]-8-oxo-,[6R- [6R,7â(E)]]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.3%

3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (24209-38-9) + 4-(diethylphosphoryl)-2-(2-amino-4-thiazolyl)-2-syn-(2-methoxyimino)acetate (179258-53-8) → (6R)-7t-[2-(2-amino-thiazol-4-yl)-2-(Z)-methoxyimino-acetylamino]-8-oxo-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (65085-01-0,66340-45-2,69738-54-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 2.5h;

DOI:10.1080/00397919808005071

Reference yield:

cefotaxime (65872-41-5) → (6R)-7t-[2-(2-amino-thiazol-4-yl)-2-(Z)-methoxyimino-acetylamino]-8-oxo-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (65085-01-0,66340-45-2,69738-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / N,N-diisopropylethylamine / dimethylformamide / 2 h / 0 - 5 °C

2: 70.3 percent / Et₃N / dimethylformamide / 2.5 h

With triethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1080/00397919808005071

Reference yield:

→ 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(1-methyl-tetrazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylic acid (65085-01-0,66340-45-2,69738-54-1)

Guidance literature:

upstream raw materials:

3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

4-(diethylphosphoryl)-2-(2-amino-4-thiazolyl)-2-syn-(2-methoxyimino)acetate

cefotaxime