2-Chloro-N-(2,6-dimethylphenyl)-N-hydroxyacetamide

Base Information

• Chemical Name: 2-Chloro-N-(2,6-dimethylphenyl)-N-hydroxyacetamide
• CAS No.: 64585-21-3
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.664
• ChEMBL ID: CHEMBL3278070
• DSSTox Substance ID: DTXSID90498412
• Wikidata: Q82348434
• Mol file: 64585-21-3.mol

Synonyms:64585-21-3;2-Chloro-N-(2,6-dimethylphenyl)-N-hydroxyacetamide;CHEMBL3278070;DTXSID90498412

Chemical Property of 2-Chloro-N-(2,6-dimethylphenyl)-N-hydroxyacetamide

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 213.0556563
• Heavy Atom Count: 14
• Complexity: 200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)C)N(C(=O)CCl)O

Technology Process of 2-Chloro-N-(2,6-dimethylphenyl)-N-hydroxyacetamide

There total 3 articles about 2-Chloro-N-(2,6-dimethylphenyl)-N-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dimethylnitrobenzene (81-20-9) → ω-Chlor-N-hydroxy-2,6-dimethylacetanilid (64585-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Zn, NH₄Cl / aq. ethanol

2: aq. NaHCO₃ / diethyl ether

With sodium hydrogencarbonate; ammonium chloride; zinc; In diethyl ether; ethanol;

DOI:10.1002/jps.2600660834

Reference yield:

N-(2,6-dimethylphenyl)hydroxylamine (3096-63-7) + chloroacetyl chloride (79-04-9) → ω-Chlor-N-hydroxy-2,6-dimethylacetanilid (64585-21-3)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether;

DOI:10.1002/jps.2600660834

Reference yield:

→ ω-Chlor-N-hydroxy-2,6-dimethylacetanilid (64585-21-3)

Guidance literature:

Hydroxylamin 11, Chloracetylchlorid;

DOI:10.1021/jm00206a001

upstream raw materials:

N-(2,6-dimethylphenyl)hydroxylamine

chloroacetyl chloride

2,6-dimethylnitrobenzene

Downstream raw materials:

ω-Diethylamino-N-hydroxy-2,6-dimethylacetanilid

ω-Ethylamino-N-hydroxy-2,6-dimethylacetanilid