Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro-

Base Information

Chemical Name:Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro-
CAS No.:64605-34-1
Molecular Formula:C9H10ClNO2
Molecular Weight:199.637
Hs Code.:

Synonyms:2-amino-5-methoxy-α-chloroacetophenone;1-(2-Amino-5-methoxy-phenyl)-2-chloro-ethanone;5-Methoxy-2-amino-α-chloracetophenon;

Suppliers and Price of Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro-

Chemical Property:

Melting Point:104 - 106 °C
Boiling Point:334.8±27.0 °C(Predicted)
PSA：52.32000
Density:1.258±0.06 g/cm3(Predicted)
LogP:2.28010

Purity/Quality:: 95% ^*data from raw suppliers

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MSDS Files:

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Technology Process of Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro-

There total 4 articles about Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 104-94-9
4-methoxy-aniline

: 107-14-2
chloroacetonitrile

: 64605-34-1
1-(2-amino-5-methoxyphenyl)-2-chloroethan-1-one

Guidance literature:: 4-methoxy-aniline; chloroacetonitrile; With boron trichloride; titanium tetrachloride; In dichloromethane; toluene; at 0 - 120 ℃;

With hydrogenchloride; water; In dichloromethane; toluene; for 1h; Reflux;

With sodium hydroxide; In dichloromethane; water; toluene; at 0 ℃; pH=4;
DOI:10.1016/j.tet.2011.07.090

Reference yield:

: C₉H₁₁ClN₂O

: 64605-34-1
1-(2-amino-5-methoxyphenyl)-2-chloroethan-1-one

Guidance literature:: With hydrogenchloride; water; In dichloromethane; Reflux; Inert atmosphere;
DOI:10.1002/adsc.201701028

Reference yield:

: 104-94-9
4-methoxy-aniline

: 64605-34-1
1-(2-amino-5-methoxyphenyl)-2-chloroethan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trichloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

1.2: 6 h / 0 °C / Reflux; Inert atmosphere

2.1: hydrogenchloride; water / dichloromethane / Reflux; Inert atmosphere

With hydrogenchloride; water; boron trichloride; In dichloromethane;
DOI:10.1002/adsc.201701028