Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro-

Base Information

• Chemical Name: Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro-
• CAS No.: 64605-34-1
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.637
• Mol file: 64605-34-1.mol

Synonyms:2-amino-5-methoxy-α-chloroacetophenone;1-(2-Amino-5-methoxy-phenyl)-2-chloro-ethanone;5-Methoxy-2-amino-α-chloracetophenon;

Chemical Property of Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro-

Chemical Property:

• Melting Point: 104 - 106 °C
• Boiling Point: 334.8±27.0 °C(Predicted)
• PSA: 52.32000
• Density: 1.258±0.06 g/cm3(Predicted)
• LogP: 2.28010

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro-

There total 4 articles about Ethanone, 1-(2-amino-5-methoxyphenyl)-2-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-methoxy-aniline (104-94-9) + chloroacetonitrile (107-14-2) → 1-(2-amino-5-methoxyphenyl)-2-chloroethan-1-one (64605-34-1)

Guidance literature:

4-methoxy-aniline; chloroacetonitrile; With boron trichloride; titanium tetrachloride; In dichloromethane; toluene; at 0 - 120 ℃;

With hydrogenchloride; water; In dichloromethane; toluene; for 1h; Reflux;

With sodium hydroxide; In dichloromethane; water; toluene; at 0 ℃; pH=4;

DOI:10.1016/j.tet.2011.07.090

Reference yield:

C9H11ClN2O → 1-(2-amino-5-methoxyphenyl)-2-chloroethan-1-one (64605-34-1)

Guidance literature:

With hydrogenchloride; water; In dichloromethane; Reflux; Inert atmosphere;

DOI:10.1002/adsc.201701028

Reference yield:

4-methoxy-aniline (104-94-9) → 1-(2-amino-5-methoxyphenyl)-2-chloroethan-1-one (64605-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron trichloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

1.2: 6 h / 0 °C / Reflux; Inert atmosphere

2.1: hydrogenchloride; water / dichloromethane / Reflux; Inert atmosphere

With hydrogenchloride; water; boron trichloride; In dichloromethane;

DOI:10.1002/adsc.201701028

upstream raw materials:

4-methoxy-aniline

chloroacetonitrile

Downstream raw materials:

2-[2-(2-amino-5-methoxy-phenyl)-2-oxo-ethyl]-2-butyrylamino-malonic acid diethyl ester

5-methoxy-3-(phenylsulfanyl)-1H-indole

4-[2-(2-chloroacetyl)-4-methoxyphenylamino]butan-2-one

1-(2-amino-5-methoxyphenyl)-2-acetyloxyethanone