N,N-Dimethyl-delta-phenylbenzenebutanamine hydrochloride

Base Information

• Chemical Name: N,N-Dimethyl-delta-phenylbenzenebutanamine hydrochloride
• CAS No.: 892-52-4
• Molecular Formula: C18H24ClN
• Molecular Weight: 289.8429
• DSSTox Substance ID: DTXSID801008700
• Mol file: 892-52-4.mol

Synonyms:892-52-4;N,N-Dimethyl-delta-phenylbenzenebutanamine hydrochloride;N,N-Dimethyl-4,4-diphenylbutylamine hydrochloride;Butylamine, N,N-dimethyl-4,4-diphenyl-, hydrochloride;SCHEMBL11374749;Benzenebutanamine, N,N-dimethyl-delta-phenyl-, hydrochloride;DTXSID801008700;N,N-Dimethyl-4,4-diphenylbutan-1-amine--hydrogen chloride (1/1)

Chemical Property of N,N-Dimethyl-delta-phenylbenzenebutanamine hydrochloride

Chemical Property:

• Vapor Pressure: 1.17E-05mmHg at 25°C
• Boiling Point: 369.6°Cat760mmHg
• Flash Point: 159.7°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 6
• Exact Mass: 289.1597275
• Heavy Atom Count: 20
• Complexity: 206

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCCC(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Technology Process of N,N-Dimethyl-delta-phenylbenzenebutanamine hydrochloride

There total 5 articles about N,N-Dimethyl-delta-phenylbenzenebutanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4,4-Diphenylbutyric Acid, N,N-Dimethyl Amide (22101-13-9) → N,N-dimethyl-4,4-diphenyl-butylamine hydrochloride (892-52-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Ambient temperature;

DOI:10.1248/cpb.38.1570

Reference yield:

4,5-dihydro-5-phenyl-2(3H)-furanone (1008-76-0) → N,N-dimethyl-4,4-diphenyl-butylamine hydrochloride (892-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / AlCl₃ / 5 h / Ambient temperature

2: 73 percent / triethylamine, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

3: 71 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With lithium aluminium tetrahydride; aluminium trichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.38.1570

Reference yield:

4,4-diphenylbutanoic acid (14578-67-7) → N,N-dimethyl-4,4-diphenyl-butylamine hydrochloride (892-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / triethylamine, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

2: 71 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With lithium aluminium tetrahydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.38.1570

upstream raw materials:

4,4-Diphenylbutyric Acid, N,N-Dimethyl Amide

4,5-dihydro-5-phenyl-2(3H)-furanone

4,4-diphenylbutanoic acid

benzene