22101-13-9

Basic information

• Product Name: N,N-dimethyl-4,4-diphenylbutanamide
• Synonyms: Benzenebutanamide, N,N-dimethyl-γ-phenyl-
• CAS NO: 22101-13-9
• Molecular Formula: C₁₈H₂₁NO
• Molecular Weight: 267.3654
• Mol File: 22101-13-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 89-91 °C
• Boiling Point: 411.5°C at 760 mmHg
• Flash Point: 184.7°C
• Density: 1.042g/cm³
• Vapor Pressure: 5.56E-07mmHg at 25°C
• Refractive Index: 1.556
• PKA: -0.47±0.70(Predicted)
• CAS DataBase Reference: N,N-dimethyl-4,4-diphenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-4,4-diphenylbutanamide(22101-13-9)
• EPA Substance Registry System: N,N-dimethyl-4,4-diphenylbutanamide(22101-13-9)

Safety Data

• Hazardous Substances Data: 22101-13-9(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 599-67-7 1,1-diphenylethanol 
• 530-48-3 1,1-Diphenylethylene 
• 127-19-5 N,N-dimethyl acetamide 
• 71-43-2 benzene 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 14578-67-7 4,4-diphenylbutanoic acid 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 892-52-4 N,N-dimethyl-4,4-diphenyl-butylamine hydrochloride 

Relevant articles and documents

Base-promoted addition of DMA with 1,1-diarylethylenes: Application to a total synthesis of (-)-sacidumlignan B

A base-promoted addition of DMA (N,N-dimethylacetamide) to 1,1-diarylethylenes has been developed, and it provides a new strategy for the synthesis of N,N-dimethyl-4,4-diarylbutanamides from 1,1-diarylethylenes at room temperature. This method allows us to achieve the goal of synthesizing (-)-sacidumlignan B, and provides simple operation and broad substrate scope by avoiding the use of transition metal catalysts.