N,N-dimethyl-4,4-diphenylbutanamide

Base Information

• Chemical Name: N,N-dimethyl-4,4-diphenylbutanamide
• CAS No.: 22101-13-9
• Molecular Formula: C18H21 N O
• Molecular Weight: 267.3654
• Mol file: 22101-13-9.mol

Synonyms:Butyramide,N,N-dimethyl-4,4-diphenyl- (8CI)

Chemical Property of N,N-dimethyl-4,4-diphenylbutanamide

Chemical Property:

• Vapor Pressure: 5.56E-07mmHg at 25°C
• Melting Point: 89-91 °C
• Boiling Point: 411.5°Cat760mmHg
• PKA: -0.47±0.70(Predicted)
• Flash Point: 184.7°C
• PSA: 20.31000
• Density: 1.042g/cm³
• LogP: 3.68690

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-dimethyl-4,4-diphenylbutanamide

There total 6 articles about N,N-dimethyl-4,4-diphenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1,1-Diphenylethylene (530-48-3) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → 4,4-Diphenylbutyric Acid, N,N-Dimethyl Amide (22101-13-9)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃; for 3h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;

DOI:10.1039/d0ob00376j

Reference yield: 73.0%

4,4-diphenylbutanoic acid (14578-67-7) + N,N-dimethylammonium chloride (506-59-2) → 4,4-Diphenylbutyric Acid, N,N-Dimethyl Amide (22101-13-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1248/cpb.38.1570

Reference yield:

1,1-diphenylethanol (599-67-7) → 4,4-Diphenylbutyric Acid, N,N-Dimethyl Amide (22101-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 6 h / 45 °C / Inert atmosphere

2: sodium hexamethyldisilazane / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere

With sodium hexamethyldisilazane; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

DOI:10.1039/d0ob00376j

upstream raw materials:

4,4-diphenylbutanoic acid

N,N-dimethylammonium chloride

4,5-dihydro-5-phenyl-2(3H)-furanone

benzene

Downstream raw materials:

N,N-dimethyl-4,4-diphenyl-butylamine hydrochloride