5-(Tetradecyloxy)-2-furoic acid

Base Information

Chemical Name:5-(Tetradecyloxy)-2-furoic acid
CAS No.:54857-86-2
Molecular Formula:C19H32 O4
Molecular Weight:324.461
Hs Code.:2932190090
UNII:BI12FRY055
DSSTox Substance ID:DTXSID60203338
Nikkaji Number:J395.152I
Wikidata:Q27089005
Pharos Ligand ID:L9S8252SN74P
ChEMBL ID:CHEMBL1562779
Mol file:54857-86-2.mol

Synonyms:5-(tetradecyloxy)-2-furancarboxylic acid;5-(tetradecyloxy)-2-furoic acid;RMI 14514;RMI-14514;TOFA

Suppliers and Price of 5-(Tetradecyloxy)-2-furoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
TOFA ≥98% (HPLC)
5mg
$ 195.00

Sigma-Aldrich
TOFA
5mg
$ 293.22

Sigma-Aldrich
TOFA ≥98% (HPLC)
25mg
$ 773.00

DC Chemicals
TOFA >98%
1 g
$ 1000.00

DC Chemicals
TOFA >98%
250 mg
$ 500.00

DC Chemicals
TOFA >98%
100 mg
$ 250.00

CSNpharm
TOFA
5mg
$ 51.00

ChemScene
TOFA 99.57%
50mg
$ 264.00

ChemScene
TOFA 99.57%
10mg
$ 72.00

ChemScene
TOFA 99.57%
5mg
$ 60.00

Total 43 raw suppliers

Chemical Property of 5-(Tetradecyloxy)-2-furoic acid

Chemical Property:

Vapor Pressure:1.41E-08mmHg at 25°C
Melting Point:112-115 °C
Boiling Point:441.7°C at 760 mmHg
Flash Point:220.9°C
PSA：59.67000
Density:1.003g/cm³
LogP:6.05770
Storage Temp.:−20°C
Solubility.:DMSO: 2.5 mg/mL
XLogP3:7.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:15
Exact Mass:324.23005950
Heavy Atom Count:23
Complexity:293

Purity/Quality:

99%, ^*data from raw suppliers

TOFA ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O
Description TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1).1 Induces apoptosis in a variety of tumor cell lines.2,3 Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells.4 TOFA impairs glucose-stimulated insulin secretion after chronic treatment.5
Uses TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).

Technology Process of 5-(Tetradecyloxy)-2-furoic acid

There total 5 articles about 5-(Tetradecyloxy)-2-furoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 112-72-1
1-Tetradecanol

: tetradecyl ester of 5-bromofuroic acid

: 54857-86-2
5-(tetradecyloxy)-2-furancarboxylic acid

Guidance literature:: 1-Tetradecanol; tetradecyl ester of 5-bromofuroic acid; With potassium tert-butylate; In tetrahydrofuran; at 45 ℃;

With methanol; potassium hydroxide; at 30 - 35 ℃;

Reference yield: 76.0%

: 2527-99-3
methyl 5-bromo-2-furoate

: 112-72-1
1-Tetradecanol

: 54857-86-2
5-(tetradecyloxy)-2-furancarboxylic acid

Guidance literature:: methyl 5-bromo-2-furoate; 1-Tetradecanol; With titanium(IV) isopropylate; In toluene; at 115 - 135 ℃; for 4h; Industrial scale;

With potassium tert-butylate; In tetrahydrofuran; toluene; at 40 - 55 ℃; Industrial scale;

With methanol; potassium hydroxide; In tetrahydrofuran; toluene; for 4h; Heating; Industrial scale;

Reference yield:

: 585-70-6
5-bromo-furan-2-carboxylic acid

: 112-72-1
1-Tetradecanol

: 54857-86-2
5-(tetradecyloxy)-2-furancarboxylic acid

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) toluene, reflux, 3 h, 2.) 60 deg C, 1 h; reflux, 16 h;
DOI:10.1002/jps.2600701002