2-Phenyl-2-(pyridin-2-yl)acetamide

Base Information

• Chemical Name: 2-Phenyl-2-(pyridin-2-yl)acetamide
• CAS No.: 7251-52-7
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 212.251
• Hs Code.: 2933399090
• European Community (EC) Number: 230-663-3
• NSC Number: 62572
• UNII: A5VMT44Z62
• DSSTox Substance ID: DTXSID90874398
• Nikkaji Number: J212.263D
• Mol file: 7251-52-7.mol

Synonyms:7251-52-7;2-phenyl-2-(pyridin-2-yl)acetamide;Phenyl-(2-pyridyl)acetamide;2-Phenyl-2-(2-pyridyl)acetamide;2-phenyl-2-pyridin-2-ylacetamide;alpha-Phenyl-2-pyridineacetamide;A5VMT44Z62;(2RS)-2-Phenyl-2-(pyridin-2-yl)acetamide;alpha-Phenylpyridine-2-acetamide;EINECS 230-663-3;MFCD00138126;NSC-62572;2-phenyl-2-(2-pyridinyl)acetamide;NSC62572;NSC 62572;pyridinylphenylacetamide;CBMicro_020816;Cambridge id 5471815;UNII-A5VMT44Z62;Oprea1_091075;SCHEMBL639563;2-Phenyl-(2-pyridyl)acetamide;alpha-(2-Pyridyl)phenylacetamide;DTXSID90874398;alpha -Phenyl-2-pyridineacetamide;CCG-8643;(RS)-phenyl-pyridin-2-yl-acetamide;STL290452;2-phenyl-2-(pyridine2-yl) acetamide;AKOS005065618;CS-W015007;AS-61754;SC-16571;.ALPHA.-PHENYL-2-PYRIDINEACETAMIDE;BIM-0020905.P001;.ALPHA.-(2-PYRIDYL)BENZENEACETAMIDE;FT-0636405;P1741;2-PYRIDINEACETAMIDE, .ALPHA.-PHENYL-;A837550;SR-01000210022;SR-01000210022-1;METHYLPHENIDATE HYDROCHLORIDE IMPURITY F [EP IMPURITY]

Chemical Property of 2-Phenyl-2-(pyridin-2-yl)acetamide

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 9.17E-07mmHg at 25°C
• Melting Point: 136 °C
• Refractive Index: 1.602
• Boiling Point: 404.8 °C at 760 mmHg
• PKA: 15.48±0.50(Predicted)
• Flash Point: 198.6 °C
• PSA: 55.98000
• Density: 1.178 g/cm³
• LogP: 2.39910
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 212.094963011
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

99.9% ^*data from raw suppliers

α-Phenyl-2-pyridineacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,F
• Hazard Codes: Xi,F

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=N2)C(=O)N
• Uses: α-Phenyl-2-pyridineacetamide (cas# 7251-52-7) is a compound useful in organic synthesis.

Technology Process of 2-Phenyl-2-(pyridin-2-yl)acetamide

There total 6 articles about 2-Phenyl-2-(pyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenyl-pyridin-2-yl-acetonitrile (5005-36-7) → 2-phenyl-2-(pyridin-2-yl)acetamide (7251-52-7,171927-46-1)

Guidance literature:

phenyl-pyridin-2-yl-acetonitrile; With sulfuric acid; at 10 - 20 ℃; for 16h;

With sodium hydroxide; In water; at 10 - 30 ℃; pH=12;

Reference yield:

conc. H2 SO4 + phenyl-pyridin-2-yl-acetonitrile (5005-36-7) → 2-phenyl-2-(pyridin-2-yl)acetamide (7251-52-7,171927-46-1)

Guidance literature:

With sodium hydroxide; In water;

Reference yield:

phenylacetonitrile (140-29-4) → 2-phenyl-2-(pyridin-2-yl)acetamide (7251-52-7,171927-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNH₂; toluene

2: aqueous H₂SO₄

With sulfuric acid; sodium amide; toluene;

DOI:10.1002/hlca.194402701222 DOI:10.1002/ardp.19532860902

upstream raw materials:

phenyl-pyridin-2-yl-acetonitrile

2-chloropyridine

phenylacetonitrile

2-bromo-pyridine

Downstream raw materials:

5-phenyl-5-pyridin-2-yl-tetrahydro-pyrimidin-4-one

(RS)-N-cyclopropylmethyl-2-phenyl-2-pyridin-2-yl-acetamide

(RS)-phenyl-pyridin-2-yl-acetic acid methyl ester

dl-erythro-α-phenyl-α-(2-piperidyl)acetamide

Refernces

• 1、 ?tengl, Milan,Chodkowski, Andrzej,Dawidowski, Maciej,El Harchi, Aziza,Hancox, Jules C.,Jarkovska, Dagmar,Konopelski, Piotr,Król, Marek,Mistrova, Eliska,Podsadni, Piotr,Popowicz, Grzegorz M.,Sviglerova, Jitka,Szuberski, Piotr,Szulczyk, Bart?omiej,Tur?o, Jadwiga,Ufnal, Marcin,Wróbel, Martyna Zofia,Zhang, Yihong. "Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide". . . Retrieved 2020/03/17.
• 2、 ?lifirski, Grzegorz,Król, Marek,Kleps, Jerzy,Podsadni, Piotr,Belka, Mariusz,B?czek, Tomasz,Siwek, Agata,Stachowicz, Katarzyna,Szewczyk, Bernadeta,Nowak, Gabriel,Bojarski, Andrzej,Kozio?, Anna E.,Tur?o, Jadwiga,Herold, Franciszek. "Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands". . p. 383 - 397. Retrieved 2019/07/19.